PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

This study identifies two specific non-coding RNAs, piR-13643 and piR-21238, that are significantly elevated in papillary thyroid carcinoma (PTC) tissues compared to normal thyroid tissues. These RNAs show promise as biomarkers for detecting PTC. The identified piRNAs exhibit better performance in distinguishing malignant nodules from benign ones compared to HBME1, a currently used biomarker. These findings suggest that piR-13643 and piR-21238 could be valuable additions to existing diagnostic tools for PTC, potentially improving early detection and accuracy.

• 1
  piR-13643 and piR-21238 were significantly upregulated in PTC tissues compared to non-cancerous tissues.
• 2
  Both piR-13643 and piR-21238 showed better performance in distinguishing malignant nodules from benign nodules than HBME1.
• 3
  The expression of piR-13643 and piR-21238 increased significantly in samples of PTC at advanced clinical stages.