Platelets in Amyloidogenic Mice Are Activated and Invade the Brain

Alzheimer's disease (AD) is a brain disease where harmful proteins accumulate. This study looks at the role of platelets, small blood cells, in AD using mice with AD-like traits. The study found more platelets in the brains of AD mice compared to normal mice. These platelets were activated and located outside of blood vessels, often interacting with brain cells called astrocytes. The research suggests that platelets might play a role in AD, potentially by interacting with astrocytes and contributing to brain degeneration. This highlights the importance of further studies on platelets in brain health and disease.

• 1
  APP-PS1 mice showed a higher number of platelets in the brain parenchyma compared to WT controls, indicating platelet invasion into the brain.
• 2
  Platelets found in the brain parenchyma of APP-PS1 mice were activated, as indicated by the expression of CD62P and morphological changes.
• 3
  Platelets in the brain parenchyma were found to be in close association with astrocytes, suggesting an interaction between these cell types.