Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Spinal cord injury (SCI) has complex causes, and current treatments mainly focus on improving symptoms rather than providing a cure. SCI can lead to inflammation, apoptosis, autophagy, and oxidative stress, all of which worsen the injury. The mTOR signaling pathway plays a crucial role in regulating these processes (inflammation, apoptosis, and autophagy) after SCI. Quercetin, a natural compound, can protect the myelin sheath, enhance antioxidant defenses, and promote nerve regeneration. This review discusses how quercetin can improve SCI by regulating the mTOR signaling pathway. It suggests that quercetin could be a potential treatment option for SCI by targeting this pathway.

• 1
  Quercetin has antioxidant and anti-inflammatory properties, promotes autophagy, and inhibits apoptosis, making it a potential drug for SCI.
• 2
  Quercetin improves the microenvironment and cell survival after SCI by regulating signaling pathways like mTOR, NF-κB, MAPK, and PI3K.
• 3
  Quercetin minimizes the expression of NLRP3 inflammation-related protein and upregulates the BDNF expression to block the JAK2/STAT3 signaling pathway.