Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway

Spinal cord injury (SCI) often leads to loss of sensory and motor functions. Current treatments are not effective enough in nerve regeneration and functional recovery. This study explores how resveratrol, found in grapes and other plants, can help with recovery after SCI. The researchers used a rat model of SCI to see if resveratrol could improve function recovery. They measured things like how well the rats could move, their sensory recovery, and the amount of damage to the spinal cord. They found that resveratrol could promote the function recovery and axonal regeneration, improve histological damage, inhibit apoptosis level after SCI through regulating Wnt/β-catenin signaling pathway.

• 1
  Resveratrol significantly improved the function recovery, promoted axonal regeneration, suppressed apoptosis after SCI in rats.
• 2
  Resveratrol activates the Wnt/β-catenin signaling pathway, which is important for cell proliferation and regeneration.
• 3
  Blocking the Wnt/β-catenin pathway with XAV939 reversed the benefits of resveratrol, indicating that resveratrol's effects are dependent on this pathway.