S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

Traumatic brain injury (TBI) can cause damage to brain cells and blood vessels. This damage can lead to more problems, like oxidative stress and inflammation. S-nitrosoglutathione (GSNO) is a molecule that can help protect the brain. This study looked at whether GSNO could reduce damage and help the brain repair itself after TBI in rats. The study found that GSNO reduced oxidative stress, protected blood vessels, and promoted brain repair mechanisms in rats with TBI. This suggests that GSNO could be a potential treatment for TBI in humans.

• 1
  GSNO treatment reduced peroxynitrite, lipid peroxides/aldehydes, BBB leakage, inflammation, and edema in the short term (4-48 hours) following TBI in rats.
• 2
  In the long term (14 days), GSNO protected axonal integrity, maintained myelin levels, promoted synaptic plasticity, and enhanced neurotrophic factor expression.
• 3
  GSNO treatment increased the levels of NO and GSH in the brain following TBI, indicating an association of antioxidant activity with GSNO.