Brain Injury Research
Browse the latest research summaries in the field of brain injury for spinal cord injury patients and caregivers.
Showing 1-10 of 128 results
S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats
Journal of Neuroinflammation, 2011 • July 6, 2011
This study investigates whether GSNO promotes neurorepair processes by reducing peroxynitrite levels and oxidative injury in rats after TBI. The results demonstrate that GSNO reduces peroxynitrite, pr...
KEY FINDING: GSNO treatment reduced peroxynitrite, lipid peroxides/aldehydes, BBB leakage, inflammation, and edema in the short term (4-48 hours) following TBI in rats.
Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice
J Comp Neurol, 2012 • October 15, 2012
This report describes an increase in sulfated CS-GAG expression in the injury core and in a tight band surrounding it, and a decrease in the number of PNNs and the level of aggrecan and phosphacan in ...
KEY FINDING: TBI resulted in an increase in the CSPGs neurocan and NG2 expression in a tight band surrounding the injury core, which overlapped with the presence of 4-sulfated CS GAGs but not with 6-sulfated GAGs.
Editorial: Neurorehabilitation in neurotrauma: treating traumatic brain and spinal cord injuries
Front. Hum. Neurosci., 2024 • September 10, 2024
The editorial highlights the global burden of TBI and SCI, emphasizing the need for innovative and effective neurorehabilitation interventions to improve functional recovery and social reintegration f...
KEY FINDING: Mild TBI survivors often experience psychiatric comorbidities like anxiety, depression, and PTSD, along with chronic pain and cardiovascular issues.
Effect of PACAP in Central and Peripheral Nerve Injuries
Int. J. Mol. Sci., 2012 • July 6, 2012
This review summarizes findings on the neuroprotective potential of PACAP in models of different traumatic nerve injuries, highlighting its role in neuronal regeneration. Endogenous PACAP and its rece...
KEY FINDING: Expression of endogenous PACAP and its specific PAC1 receptor is elevated in different parts of the central and peripheral nervous system after traumatic injuries.
Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury
Cell Death and Disease, 2013 • April 4, 2013
This study investigates the role of SHP-1, an intracellular protein tyrosine phosphatase, in axonal reorganization and functional recovery after brain injury. The researchers hypothesized that SHP-1 n...
KEY FINDING: SHP-1 expression and activity increase in the contralesional cortex (the side opposite the injury) after a unilateral motor cortex injury.
Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts
eClinicalMedicine, 2024 • December 1, 2024
This meta-analysis used data from the CENTER-TBI and TRACK-TBI studies to explore whether polygenic risk scores (PRS) for PTSD and major depressive disorder (MDD) are associated with the development o...
KEY FINDING: PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30–1.84, p < 0.001].
Differential brain activity in patients with disorders of consciousness: a 3-month rs-fMRI study using amplitude of low-frequency fluctuation
Frontiers in Neurology, 2024 • December 13, 2024
This study used rs-fMRI and ALFF to examine brain activity differences in DoC patients with TBI and non-TBI, assessing the predictive value of these measures for consciousness improvement after SCS th...
KEY FINDING: Patients with TBI showed increased ALFF in the thalamus and anterior cingulate cortex, while the middle occipital lobe showed decreased ALFF.
Adult Born Dentate Granule Cell Mediated Upregulation of Feedback Inhibition in a Mouse Model of Traumatic Brain Injury
The Journal of Neuroscience, 2022 • September 14, 2022
The study investigates the role of adult-born dentate granule cells (DGCs) in feedback inhibition and recurrent excitation in the dentate gyrus following traumatic brain injury (TBI) using a controlle...
KEY FINDING: Activation of DGCs born before CCI increased feedback inhibition in mature DGCs and excitation in parvalbumin-expressing basket cells (PVBCs) compared to sham controls.
Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy
Neural Regen Res, 2023 • February 1, 2023
Spinal cord injury (SCI) is now considered not only as an event restricted to the spinal cord but also as a brain neurodegenerative disease because the hippocampus undergoes chronic alterations as a c...
KEY FINDING: Spinal cord injury (SCI) induces cognitive and mood deficits that are not induced by lifestyle changes, drugs of abuse, and combined medication but are related to changes in brain structures involved in cognition and emotion, such as the hippocampus.
Proposal of a Management Algorithm to Predict the Need for Expansion Duraplasty in American Spinal Injury Association Impairment Scale Grades A–C Traumatic Cervical Spinal Cord Injury Patients
Journal of Neurotrauma, 2022 • December 1, 2022
The study aimed to determine indications for expansion duraplasty in addition to adequate laminectomy in patients with AIS grades A-C tCSCI. The extent of the posterior cervical decompression was base...
KEY FINDING: Patients with sport injuries and inadequate decompression were suitable candidates for expansion duraplasty.