SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability

This study examines the use of convalescent plasma (CP) from recovered COVID-19 patients as a treatment, focusing on identifying donors with sufficient antibody levels and determining the best time frame for plasma donation. Researchers analyzed 189 CP donations from 66 donors, measuring anti-SARS-CoV-2 IgG antibody levels and their functionality. The study found a correlation between IgG levels and antibody effectiveness, allowing prediction of the optimal donation period. The findings suggest that plasma collection centers can use standard IgG ratio values to determine the ideal times for CP donation, ensuring the most effective plasma products are used for treating COVID-19 patients.

• 1
  There is a significant correlation between semi-quantitative SARS-CoV-2 IgG ratio values and in vitro antibody functionality.
• 2
  High IgG ratio values correlate with high in vitro antibody functionality and are suitable for CP donation for a median of 134 days after the first donation.
• 3
  Donors with lower IgG ratios are suitable for donation for a median of 53 days.