Spinal cord injury can be relieved by the polysaccharides of Tricholoma matsutake by promoting axon regeneration and reducing neuroinflammation

Spinal cord injuries (SCIs) are becoming more common in China and often lead to limb dysfunction. Inflammation after SCI contributes to the problem. This study looks at how Tricholoma matsutake polysaccharides (TMP) might help with recovery after SCI. The study found that TMP promotes nerve growth and reduces inflammation in cells. In mice with SCI, TMP improved nerve regeneration and reduced inflammation.

• 1
  TMP promoted neurite growth and inhibited the production of TNFα, IL-6, and NF-kappa B in cells treated with hydrogen peroxide.
• 2
  In mice with SCI, TMP treatment led to a significant increase in BMS scores and nerve regeneration compared to the SCI group.
• 3
  TMP treatment in mice with SCI significantly decreased NF-kappa B signaling, TNFα, and IL-6 production.