Neuroscience Bulletin, 2019 · DOI: https://doi.org/10.1007/s12264-018-0320-9 · Published: December 17, 2018
This review explores the potential of spinal cord stimulation (SCS) for treating chronic pain following spinal cord injury (SCI). Alleviating pain is crucial for improving the quality of life for SCI patients, alongside restoring other functions. SCS, which involves using electrical pulses to modulate nerve activity, has been used for managing various chronic pain conditions. However, its effectiveness and mechanisms in SCI pain are not fully understood due to limited research and methodological issues in past studies. The review outlines different SCS approaches for SCI pain, including conventional, burst, and high-frequency stimulation. It also discusses the challenges of treating SCI pain and future research directions for improving SCS therapy.
SCS treatment should be tailored to each SCI patient based on their residual neuronal substrates and functional status.
Exploring the potential of combining SCS with other neuromodulation modalities, such as oscillating spinal field stimulation, may improve outcomes.
Additional research is needed to understand the underlying mechanisms of SCS and identify the optimal SCS parameters and patient selection criteria.