Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury

This study explores a new method for treating spinal cord injuries (SCI) using mineral-coated microparticles (MCMs) to deliver Interleukin-10 (IL-10) directly to the injury site. The goal was to provide a local, sustained release of IL-10, an anti-inflammatory cytokine, to reduce inflammation and promote tissue repair after SCI. The researchers found that this targeted delivery method improved motor function and reduced inflammation in rats with SCI, suggesting a potential new approach for treating these injuries.

• 1
  MCMs effectively delivered IL-10 to the injury site, resulting in elevated IL-10 levels and suppressed inflammatory cytokines.
• 2
  Rats treated with MCMs+IL-10 showed a significant reduction in inflammatory macrophages and an increase in anti-inflammatory macrophages.
• 3
  The MCMs+IL-10 group exhibited significantly higher functional scores compared to the control group 28 days post-injury, indicating improved motor function.