The Effect of Amniotic Tissue on Spinal Interventions: A Systematic Review

International Journal of Spine Surgery, 2022 · DOI: 10.14444/8380 · Published: October 12, 2022

Simple Explanation

Amniotic membrane tissue has been considered to potentially enhance healing in various soft tissue conditions. Recent studies suggest its therapeutic potential for spinal pathologies. This review summarizes existing research on the clinical use of amniotic membrane-derived agents and their impact on outcomes after spinal surgery. The systematic review provides a summary of the existing literature regarding the use of amniotic membrane preparations, treatment regimens, and indications within spinal surgery.

Study Duration

Not specified

Participants

12 studies (4 clinical studies and 8 studies utilizing animal models)

Evidence Level

Level 4. Systematic Review

Key Findings

1
Amnion products show promising effects in reducing epidural adhesions and scar tissue after spine surgery.
2
Amnion products may improve spinal fusion rate and postoperative pain scores.
3
Amnion products have the potential to promote better functional outcomes after spine surgery.

Research Summary

This systematic review summarizes the existing literature regarding the use of amniotic membrane preparations, treatment regimens, and indications within spinal surgery. The review of reported studies revealed a wide variety of amniotic membrane preparations, treatment regimens, and indications, which limit definitive conclusions. Aggregate results demonstrate promising basic science and outcomes potential in spinal surgery, but further study is warranted to determine whether this application is appropriate in the clinical setting.

Practical Implications

Concise Summary for Physicians

Provides a concise summary on the outcomes and indications associated with amniotic membrane products, useful given the growing popularity of these agents in orthopedic and neurologic surgery.

Future Research

Highlights the need for further research to determine whether the application of amniotic tissues is appropriate in the clinical setting.

Clinical Decision Making

Helps clinicians understand the potential benefits of amniotic membrane-derived products in reducing epidural adhesions and scar tissue, improving spinal fusion rate and postoperative pain scores, and promoting better functional outcomes after spine surgery.

Study Limitations

1
Limited number of reported studies.
2
Wide variety of amniotic membrane preparations, treatment regimens, and indications.
3
Lack of definitive clinical proof that amniotic tissues enhance tissue repair or regeneration.

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