The Translation of Nanomedicines in the Contexts of Spinal Cord Injury and Repair

This review discusses the potential of nanomedicine for treating spinal cord injuries (SCI). Nanomedicine involves using tiny particles to deliver drugs and promote tissue repair. The review highlights advances in using nanoparticles to deliver drugs, modulate biological responses, and reconstruct damaged tissue after SCI. It also covers recent progress in combinatorial therapy using stem cells and engineered nanoparticles. The review emphasizes the importance of understanding the biological complexities of SCI and the regulatory landscape to effectively translate nanomedicine research into clinical applications.

• 1
  Nanoparticle size, shape, and surface chemistry are critical factors influencing their interaction with biological systems, affecting drug delivery and cellular uptake in SCI treatment.
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  Cellular nanotherapeutics, involving stem cells and cell-derived entities like exosomes, show promise in modulating histological, anatomical, and behavioral outcomes in SCI.
• 3
  Cell-free nanotherapeutics, using nanomaterials to deliver therapeutic agents without direct cell involvement, offer targeted delivery but face translational challenges and require further research for clinical efficacy.