Transgenic Analysis of Signaling Pathways Required for Xenopus Tadpole Spinal Cord and Muscle Regeneration

The study investigates the signaling pathways necessary for spinal cord and muscle regeneration in Xenopus tadpoles. Two methods were employed: grafting transgenic spinal cord and using the Tet-on system to express inhibitors in specific tissues. The findings indicate that both spinal cord and muscle regeneration rely on the Wnt-β-catenin and Fgf pathways.

• 1
  Both spinal cord and muscle regeneration depend on the Wnt-β-catenin and the Fgf pathways.
• 2
  Reduction of spinal cord regeneration impairs the regeneration of other tail components, including muscles.
• 3
  In contrast, reduced muscle regeneration does not affect spinal cord regeneration.