Browse the latest research summaries in the field of chemical biology for spinal cord injury patients and caregivers.
Showing 1-3 of 3 results
ACS Chem Neurosci, 2022 • March 2, 2022
This study introduces novel small molecules, HJ-01 and HJ-02, designed to promote nerve regeneration through CSPG-containing scars by targeting PTPσ. These compounds restore nerve growth in vitro at n...
KEY FINDING: HJ-01 and HJ-02 restore sympathetic axon outgrowth over inhibitory CSPGs in a dose-dependent manner.
Biomaterials, 2012 • January 1, 2012
This study explores the use of glycomimetic-functionalized collagen as a biomaterial for neural tissue engineering. Type I collagen scaffolds were functionalized with peptide mimics of polysialic acid...
KEY FINDING: Grafted HNK-1 encouraged motor neuron outgrowth, but not sensory neuron outgrowth, maintaining modality-specific responses.
Dev Dyn, 2021 • June 1, 2021
This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...
KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).