Gastroenterology Research

KEY FINDING: The gut microbiome composition differs significantly among individuals with A-SCI, L-SCI, and AB controls, as demonstrated by differences in both the alpha- and beta-diversity indices.

KEY FINDING: SCI patients show distinct dysbiotic signatures, including an increase in potentially pathogenic bacteria and a depletion of short-chain fatty acid producers.

KEY FINDING: Minocycline had a profound acute effect on the microbiota diversity and composition, which was paralleled by the subsequent normalization of spinal cord injury-induced suppression of cytokines/chemokines.

KEY FINDING: The content validity of the Persian version of Wexner’s questionnaire was acceptable, indicating that the questions were relevant and understandable to the target population.

KEY FINDING: Diversity of the gut microbiota in SCI group was reduced, and with an increase in the degree of damage, alpha diversity had decreased gradually.

KEY FINDING: PSIMA increased the faecal water content of SCI rats by 5–13%.

KEY FINDING: LcS did not significantly reduce the overall occurrence of AAD at 30 days in the entire SCI patient group (45% vs 42.1%, p = 0.639).

KEY FINDING: The patient was diagnosed with a giant fecaloma due to chronic functional constipation, a condition where stool is withheld, leading to a large mass of impacted feces.

KEY FINDING: Lidocaine did not provide any benefit in terms of severity of AD during bowel care based on all metrics of AD classification.

KEY FINDING: EA and FMT treatment facilitated intestinal transmission functional recovery and restored the colon morphology of SCI rats.