Neuroplasticity Research

KEY FINDING: Regenerated proprioceptive afferents can evoke measurable monosynaptic CDPs, unlike controls, indicating a functional change after axotomy.

KEY FINDING: ChABC normalizes deafferentation-induced compromise of sensory function. Spared-root-lesioned animals treated with ChABC did not show a deficit in their ability to sense the presence of the tape or the ability to remove the tape on any of the postinjury testing days.

KEY FINDING: Dysregulation of cathepsins, particularly after spinal cord injury, exacerbates inflammation and damages tissue, disrupting processes like autophagy and lysosomal function.

KEY FINDING: BWS robotic-assisted step training can lead to changes in spinal reflex pathways in patients with SCI or stroke, including re-emergence of physiological phase modulation.

KEY FINDING: Diffusion tensor imaging showed significant differences in the CST of SCI subjects compared to controls in areas such as the pyramids, internal capsule, cerebral peduncle, and hand area.

KEY FINDING: Multi-disciplinary approaches are critical for therapeutic techniques to realize their full potential, suggesting that well-timed, goal-directed therapy and positive feedback mechanisms are necessary for axonal sprouting and lasting functional improvement.

KEY FINDING: Significant decrease in soma volume and reduced soma expression of choline acetyltransferase (ChAT) in the intermediolateral cell column (IML) of T1 spinal cord were observed at 1 week.

KEY FINDING: Post-stroke axonal sprouting occurs in mice, rats, primates and humans, suggesting it's a conserved response to brain injury.

KEY FINDING: PTPr peptide significantly improved ipsilateral hemidiaphragm function, as assessed in vivo with electromyography recordings.

KEY FINDING: NCS1 overexpression in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.