Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 151-159 of 159 results
Respir Physiol Neurobiol, 2019 • July 1, 2019
This review discusses how local circulatory control and oxygen delivery in the spinal cord regulate different pathways to phrenic motor plasticity. Acute intermittent hypoxia (AIH) elicits distinct me...
KEY FINDING: Moderate AIH induces serotonin-dependent pLTF, which is independent of tissue hypoxia and relies on carotid body chemoreceptor activation.
Brain Sci., 2018 • December 16, 2018
The present study examined bilateral cortical organization in individuals with chronic incomplete cervical SCI and uninjured controls. Several novel findings were revealed that provide new information ...
KEY FINDING: Muscle representations in SCI are shifted medially compared to controls.
J. Exp. Med., 2019 • November 4, 2019
This study investigates how neuronal circuits remodel after spinal cord injury, focusing on the role of neuronal activity in target selection during corticospinal tract (CST) rewiring. The researchers...
KEY FINDING: NMDAR signaling and CREB-mediated transcription are essential for maintaining nascent corticospinal tract (CST)–relay neuron contacts during circuit remodeling after spinal cord injury.
The Journal of Neuroscience, 1981 • July 1, 1981
The study demonstrates that the somatotopic mapping of medial dorsal horn cells in rats changes within 4-5 days after peripheral transection of afferents, leading to novel receptive fields. Afferents ...
KEY FINDING: Peripheral nerve transection leads to a reorganization of the spinal cord sensory map, with deafferented cells acquiring novel receptive fields on the thigh, lower back, or perineum.
Neural Plasticity, 2017 • September 12, 2017
This study demonstrates that injured RtST axons can rewire and form new connections with PrINs after SCI, which is associated with improved locomotor performance. The timing of the SCI plays a critica...
KEY FINDING: Rats with a delayed staggered SCI (dSTAG) showed significantly more RtST-PrIN contacts in the grey matter compared to those with a concomitant staggered SCI (cSTAG).
EMBO reports, 2013 • August 9, 2013
The study investigates the role of STAT3 in corticospinal tract (CST) remodeling after spinal cord injury (SCI). It finds that sustained activation of STAT3 enhances remodeling of lesioned CST fibers ...
KEY FINDING: Endogenous STAT3 expression after spinal cord injury is transient and does not significantly contribute to axonal remodeling.
The Journal of Neuroscience, 2017 • November 8, 2017
This study investigates whether intraspinal chondroitinase ABC (ChABC) can augment plasticity of the corticospinal tract (CST) and improve recovery even during chronic stroke. The results showed that ...
KEY FINDING: Chondroitinase ABC (ChABC) injections into the spinal cord during chronic stroke induced significant sprouting of corticospinal axons originating in the peri-infarct cortex, indicating increased structural plasticity.
Neuroscience, 2014 • December 26, 2014
Plasticity is the basis for behavioral changes, involving neural network shaping and synaptic remodeling. Brain reorganization after CNS lesions plays a role in recovery and rehabilitation but can als...
KEY FINDING: Cortical reorganization after spinal cord injury is species-dependent, with varying degrees and patterns observed in humans, non-human primates, and rats.
The Journal of Neuroscience, 1984 • February 1, 1984
The study investigates the effect of Carbocaine on nerve sprouting and synapse formation in frog muscles. Carbocaine induces muscle fiber degeneration and subsequent regeneration, affecting nerve inne...
KEY FINDING: Carbocaine application leads to degeneration and regeneration of muscle fibers.