Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 111-120 of 2,298 results
BMC Biology, 2012 • December 17, 2012
This study demonstrates that axolotls can regenerate their lenses during a specific developmental window, challenging previous assumptions. The axolotl's lens regeneration process differs from both fr...
KEY FINDING: Axolotls can regenerate lenses from the iris within a specific time window after hatching, starting at stage 44 and lasting for about two weeks.
Korean J Physiol Pharmacol, 2012 • December 1, 2012
This study investigates the therapeutic potential of human mesenchymal stem cells (hMSCs) and a polymer scaffold in promoting functional recovery after spinal cord hemisection in rats. The researchers...
KEY FINDING: Functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation.
Mol Neurobiol, 2013 • June 1, 2013
Human umbilical cord blood (hUCB) is a rich source of multiple stem cells and is easy to harvest and purify. Human UC/UCB-derived cells can differentiate into multiple cell types of neural lineages an...
KEY FINDING: Human UCB and UCB-derived cells can survive in injured sites in animal models of ischemic brain damage and spinal cord injuries, and promote survival and prevent cell death of local neurons and glia.
PLoS ONE, 2012 • December 21, 2012
This study investigates the role of contactin-2 in spinal cord regeneration in adult zebrafish, finding that its expression is upregulated after injury. Using morpholino-mediated knockdown, the resear...
KEY FINDING: Contactin-2 mRNA and protein levels are upregulated along the central canal after spinal cord injury in adult zebrafish, suggesting a role in regeneration.
Int. J. Biol. Sci., 2013 • December 22, 2012
The study investigates the therapeutic potential of transplanting glial-restricted precursor-derived astrocytes (GDAs) expressing the neurotrophin D15A into rats with spinal cord injuries (SCI). The r...
KEY FINDING: Transplantation of D15A-GDAs significantly increased the spared white matter and decreased the injury size compared to control groups.
PLoS ONE, 2012 • December 27, 2012
This study demonstrates that pre-evaluated safe hiPSC-NS/PCs can promote functional recovery after SCI in a common marmoset model without causing tumor formation. The transplanted cells survived and d...
KEY FINDING: Grafted hiPSC-NS/PCs survived and differentiated into neurons, astrocytes, and oligodendrocytes without tumor formation in the injured spinal cord of common marmosets.
STEM CELLS AND DEVELOPMENT, 2013 • May 1, 2013
This study investigates the paracrine interactions between olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs) from different sources (adipose tissue, bone marrow, and umbilical cord)...
KEY FINDING: The secretome of OECs positively affects the metabolic activity and proliferation of MSCs, especially ASCs.
PLoS ONE, 2013 • January 21, 2013
This study provides evidence that agmatine treatment leads to lasting improvements of structure and function after spinal cord injury (SCI). Agmatine modulates BMP-2/4/7 expressions in neurons, oligod...
KEY FINDING: Agmatine treatment improved locomotor recovery and bladder function in mice with SCI.
J Hand Surg Am, 2013 • March 1, 2013
The study evaluated the effectiveness of a supercharge end-to-side (SETS) nerve transfer in augmenting recovery from incomplete nerve injuries in a rat model. The SETS procedure was performed in conju...
KEY FINDING: SETS transfer significantly increased myelinated axonal counts in the distal tibial nerve compared to the IRM and SETS groups at 5 and 8 weeks.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • January 1, 2013
This study established a novel rat SCI model involving spinal cord transection and spine shortening to ensure complete axonal transection. The results indicated that axonal regeneration was inhibited ...
KEY FINDING: Uncoordinated movements of the hind limbs were observed at 4 weeks after surgery, but coordinated movements were not observed by the end of the 12-week experiment.