Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,221-2,230 of 2,298 results
The Journal of Neuroscience, 2009 • April 29, 2009
This study demonstrates that α9 integrin expression promotes neurite outgrowth on tenascin-C (TN-C) both in vitro and in vivo, suggesting a potential therapeutic strategy for enhancing axon regenerati...
KEY FINDING: Expression of α9 integrin in PC12 cells and adult rat DRG neurons promotes extensive neurite outgrowth on tenascin-C in vitro.
JOURNAL OF NEUROTRAUMA, 2009 • October 1, 2009
The study demonstrates that a biodegradable polymer scaffold loaded with Schwann cells supports axon regeneration after spinal cord transection in rats. Fast Blue retrograde tracing was used to quanti...
KEY FINDING: Axons regenerated bidirectionally through the PLGA scaffolds after cord transection.
J Comp Neurol, 2009 • July 10, 2009
This study demonstrates that fresh-water turtles can reconnect their completely transected spinal cord leading to some degree of recovery of the motor functions lost after injury. The reconnection inv...
KEY FINDING: Some turtles regained the ability to perform stepping locomotion after spinal cord transection, although slower than normal.
Cell Mol Neurobiol, 2009 • June 17, 2009
This study compared the effects of undifferentiated and differentiated adipose tissue-derived stromal cells (ADSCs) on functional recovery after spinal cord injury (SCI) in rats. ADSCs were differenti...
KEY FINDING: Transplantation of uADSCs, dADSC-P1, and dADSC-P2 all significantly improved locomotor functional recovery in SCI rats compared to saline-treated controls.
Neurosci Lett, 2009 • June 12, 2009
Spinal cord injury (SCI) results in direct mechanical trauma followed by secondary responses, leading to paralysis and loss of sensation. Current treatment options are inadequate, necessitating therap...
KEY FINDING: SCs can fill cystic cavities, increase white matter sparing, myelinate axons, and promote axonal regeneration in various SCI models.
Neurosci Lett, 2009 • June 12, 2009
Transplantation of OECs or SCs into demyelinated or traumatic spinal cord injuries can improve functional outcome. The formation of cellular tunnels by OECs in the transected spinal cord through which...
KEY FINDING: OECs build unique cellular tunnels through which axons regenerate across a spinal cord transection lesion site.
The Journal of Neuroscience, 2009 • May 13, 2009
The study demonstrates that blocking Nogo receptor ligands with sNgR promotes the regeneration of myelinated sensory axons after dorsal root crush in adult rats. sNgR treatment leads to the regrowth o...
KEY FINDING: Intraventricular infusion of sNgR for 1 month results in extensive regrowth of myelinated sensory axons into the white and gray matter of the dorsal spinal cord.
Exp Neurol, 2010 • May 1, 2010
This study introduces an in vitro model of adult mammalian nerve repair, combining spinal cord slices with peripheral nerve grafts. The model allows for real-time imaging of axon regeneration and prec...
KEY FINDING: Adult nerve grafts remain viable in the co-culture system, maintaining their structure and function, as evidenced by Schwann cell morphology and growth factor expression.
PNAS, 2009 • June 9, 2009
The study uses 2-photon microscopy to monitor vascular and axonal network changes in living mice after spinal cord lesion, observing regrowth of injured axons and transient upregulation of blood vesse...
KEY FINDING: Injured axons show early explorative sprouting, resulting in extensive regrowth until and past the lesion site within 2 months.
J. Comp. Neurol., 2009 • August 20, 2009
This study investigates serotonergic innervation in the caudal spinal stump of rats after complete spinal transection, focusing on the impact of olfactory ensheathing glia (OEG) transplantation. The r...
KEY FINDING: Many 5-HT-labeled axons are present throughout the caudal stump of both media- and OEG-injected rats after complete spinal cord transection, suggesting the presence of 5-HT-labeled fibers is not a reliable indicator of regeneration.