Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 41-50 of 2,298 results
PNAS, 2011 • October 4, 2011
This study investigated the therapeutic potential of human-induced pluripotent stem cell-derived neurospheres (hiPSC-NSs) for treating spinal cord injury (SCI) in mice. The findings demonstrated that ...
KEY FINDING: Transplanted hiPSC-NSs survived, migrated, and differentiated into neurons, astrocytes, and oligodendrocytes within the injured spinal cord of mice.
PLoS ONE, 2011 • September 16, 2011
This study explores the role of long-distance signals and the spinal cord during tadpole tail regeneration using laser ablation and geometric morphometrics. The findings suggest that an undamaged spin...
KEY FINDING: Damage to the dorsal midline, particularly the spinal cord, affects regenerate morphology up to 24 hours post-amputation.
The Journal of Neuroscience, 2011 • October 5, 2011
This study identifies leukocyte common antigen-related phosphatase (LAR) as a functional receptor for chondroitin sulfate proteoglycans (CSPGs), which are known axon growth inhibitors. The researchers...
KEY FINDING: CSPGs bind to the LAR phosphatase with high affinity in COS-7 cells, indicating a direct interaction between these molecules.
J. Cell. Mol. Med., 2012 • July 1, 2012
This study investigated the therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta. The results suggest that prenatal MSC transplantati...
KEY FINDING: Transplanted MSCs survived in the defective spinal cord of rat foetuses with induced neural tube defects.
Orthopaedic Surgery, 2009 • May 1, 2009
This study evaluated the efficacy of cell therapy using fetal spinal cord cells (FSCC) and/or Schwann cells (SC), with or without growth factors (NGF and BDNF), in a rat model of spinal cord injury. T...
KEY FINDING: A combination of FSCC and SC resulted in better recovery than either cell type alone, suggesting a synergistic effect.
PLoS ONE, 2011 • October 14, 2011
This study investigates the role of histone deacetylases (HDACs) in Xenopus tadpole tail regeneration. It demonstrates that HDAC activity, particularly that of HDAC1, is required for the early stages ...
KEY FINDING: HDAC1 is expressed during the first two days of tail regeneration in mesenchymal cells of the regeneration bud.
BMC Developmental Biology, 2011 • November 15, 2011
The study characterizes tail regeneration in Xenopus tropicalis tadpoles and creates a transcriptomic resource to identify genes and processes modulated during vertebrate tissue repair and regeneratio...
KEY FINDING: Xenopus tropicalis tadpoles can regenerate their tails, including the spinal cord, muscle, and major blood vessels, similar to Xenopus laevis.
PLoS ONE, 2011 • November 11, 2011
This study investigates the roles of Nogo receptors NgR1 and NgR2 in the regulation of CD4 T helper responses and CNS repair during experimental autoimmune encephalomyelitis (EAE). The researchers fou...
KEY FINDING: Genetic deletion of NgR1 and NgR2 does not promote functional recovery during EAE.
The Journal of Clinical Investigation, 2012 • January 1, 2012
This study demonstrates the neuroregenerative potential of human dental pulp stem cells (DPSCs) in treating spinal cord injury (SCI). DPSCs were transplanted into rats with completely transected spina...
KEY FINDING: Transplantation of human dental pulp stem cells (DPSCs) into completely transected rat spinal cords resulted in marked recovery of hind limb locomotor functions compared to controls.
Trends Neurosci, 2012 • March 1, 2012
The review focuses on recent advances in sensory axon regeneration, particularly the ability of sensory axons to reconnect with their original synaptic targets after spinal cord injury. It discusses t...
KEY FINDING: Inactivation of inhibitory molecules like Nogo and chondroitin sulfate proteoglycans, as well as the administration of neurotrophic factors such as NGF, NT-3, GDNF, and artemin, can promote anatomical and functional regeneration across the DREZ.