Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 491-500 of 607 results
Bioengineering, 2023 • March 7, 2023
The study established a metaphyseal femoral non-union model in osteoporotic rats by comparing a piezoelectric saw versus a manual Gigli wire saw for osteotomy creation. Osteoporotic phenotype was indu...
KEY FINDING: Ovariectomized rats showed a significant reduction in cancellous and total bone mineral density compared to control rats, confirming the development of osteoporosis.
BMJ Case Rep, 2013 • January 1, 2013
Hirayama disease, also known as monomelic amyotrophy or juvenile spinal muscular atrophy of the distal upper extremity features the impairment of the anterior horn cells of the distal cervical spinal ...
KEY FINDING: A 17-year-old boy with scoliosis presented with progressive muscle weakness and atrophy in his left upper limb over 6 months.
Spinal Cord Series and Cases, 2018 • September 4, 2018
This case report highlights the rare but severe complication of Charcot spinal arthropathy (CSA) following spinal cord injury, leading to significant spinal disruption and aortic displacement. The pat...
KEY FINDING: The patient presented with a 48-year history of T3 AIS A paraplegia. He experienced painless low back crepitance.
Spinal Cord Series and Cases, 2017 • August 31, 2017
The Austrian Spinal Cord Injury Study (ASCIS) collects longitudinal data on simple forms within a 7-stage follow-up examination timeline. ASCIS is uniquely positioned in Austria to capture detailed in...
KEY FINDING: The implementation of the ASCIS in 2012 created the first nationwide SCI patient registry in Austria.
The Journal of Spinal Cord Medicine, 2006 • August 1, 2006
This clinical practice guideline offers recommendations for bladder management in adults with spinal cord injury (SCI), aiming to preserve the upper urinary tract, minimize lower urinary tract complic...
KEY FINDING: The guideline provides evidence-based recommendations for different bladder management methods, such as intermittent catheterization, indwelling catheterization, and reflex voiding, considering factors like hand function, cognitive ability, and individual preferences.
Front. Neural Circuits, 2017 • November 6, 2017
Finding a treatment for spinal cord injury (SCI) focuses on reconnecting the spinal cord by promoting regeneration across the lesion site. However, while regeneration is necessary for recovery, on its...
KEY FINDING: Synaptic inputs from individual regenerated axons also matched the properties in unlesioned animals, although this was associated with changes in release parameters.
ONCOLOGY LETTERS, 2021 • January 1, 2021
The present study aimed to describe the clinical characteristics, and to construct and validate nomograms for patients with non‑metastatic Ewing sarcoma. Age, sex, tumor extension and surgery were in...
KEY FINDING: Age, tumor extension, sex, International Classification of Diseases for Oncology, 3rd Edition histology, surgery and chemotherapy were identified as independent risk factors for OS and CSS.
Nature Communications, 2024 • June 14, 2024
This study identifies dos-3 as a key gene mediating the cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of germline stem/progenitor cells (GSPCs) in C. elegans. DOS-3, a non-...
KEY FINDING: dos-3 encodes a non-canonical Notch ligand and is upregulated by DAF-16/FOXO activity in aging PSG cells of animals with reduced IIS.
Frontiers in Neurology, 2024 • September 13, 2024
The study identified CELF4 as a central gene associated with immune infiltration among DEGs through bioinformatics analysis of microarray datasets. Previous research indicates that CELF4 may play a cr...
KEY FINDING: A total of 5,151 differentially expressed genes (DEGs) were identified between SP-EP and normal samples. These DEGs are involved in cellular processes like cell cycle regulation and cell sensitivity mechanisms, according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
JOURNAL OF NEUROTRAUMA, 2010 • November 1, 2010
This study developed and characterized a graded model of C5 hemicontusion in adult male rats using a widely used rodent spinal cord impactor. Deficits in skilled and unskilled forelimb function and lo...
KEY FINDING: Graded cervical hemicontusion SCI induced quantifiable deficits in skilled and unskilled forepaw use and locomotion.