Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 51-60 of 104 results
Neurospine, 2023 • June 1, 2023
This study assessed the relationship between static and dynamic factors and the severity of cervical myelopathy in OPLL patients. The study found that minimal SAC, Cobb angle, total ROM, and local ROM...
KEY FINDING: Minimal space available for the spinal cord (SAC), C2–7 Cobb angle, total range of motion (ROM), and local ROM were identified as independent predictors of myelopathy in OPLL patients.
Tissue Eng Regen Med, 2024 • April 5, 2024
The study investigates cell therapy for syringomyelia using MSCs and iNSCs in a rat model with focal dilatation of the central canal, aiming to reduce cavity size and alleviate neuropathic pain. Resul...
KEY FINDING: Cell transplantation promotes syrinx shrinkage and stimulates ependymal cell proliferation, with effects related to transplantation location; reactions occur only when cells are transplanted into the cavity.
Journal of Translational Medicine, 2025 • February 11, 2025
This study investigates the role of Follistatin-like 1 (FSTL1) in nucleus pulposus-derived mesenchymal stem cell (NP-MSC) apoptosis and intervertebral disc degeneration (IVDD). The findings reveal tha...
KEY FINDING: FSTL1 expression is elevated in NP-MSCs from degenerated intervertebral discs in both humans and rats.
Neurosurgery, 2019 • January 1, 2019
This study investigates the potential of nucleus pulposus (NP)-like cells (NPCs) derived from human umbilical cord mesenchymal stem cells (MSCs) to restore degenerated intervertebral discs (IVDs) usin...
KEY FINDING: NPCs derived from MSCs expressed NP-specific genes (SOX9, ACAN, COL2, FOXF1, and KRT19).
Global Spine Journal, 2025 • June 27, 2024
This systematic review and meta-analysis evaluated the utility of diffusion tensor imaging (DTI) in diagnosing and assessing degenerative cervical myelopathy (DCM). It analyzed 57 studies involving ov...
KEY FINDING: Fractional anisotropy (FA) values are significantly lower in DCM patients compared to healthy subjects at the maximal compression level.
Anim Models Exp Med, 2025 • January 1, 2025
The study established a rat model of spinal cord compression and decompression to investigate SCII following decompressive cervical laminectomy. The model showed that spinal cord decompression leads t...
KEY FINDING: Spinal cord compression led to abnormal mechanical pain and decreased forepaw grip strength in rats.
BMC Musculoskeletal Disorders, 2024 • November 19, 2024
This retrospective study compared laminoplasty with selective unilateral pedicle screw fixation and laminectomy with bilateral lateral mass screw fixation for treating cervical hyperextension injury c...
KEY FINDING: Both surgical procedures led to significant improvements in postoperative AISA scores compared to preoperative scores, indicating enhanced neurological function after surgery.
Am J Transl Res, 2024 • December 30, 2024
This review explores the pathogenesis and treatment of scoliosis in adult Type 1 Chiari malformation patients with syringomyelia (CIM-SM), highlighting the complexities of surgical intervention. Key a...
KEY FINDING: Adult CIM patients often have more severe clinical manifestations, including brainstem and cranial nerve compression, leading to scoliosis deformities being overlooked.
Fluids and Barriers of the CNS, 2025 • February 10, 2025
This study investigates the role of ependymal cilia and AQP4 in syringomyelia using a rat model. The findings highlight the significance of cilia on ependymal cells and the evolving microenvironment p...
KEY FINDING: Ependymal cilia are significantly reduced in syringomyelia, with altered morphology, and cell junctions between ependymal cells are loose and broken.
Korean J Radiol, 2015 • November 1, 2015
The study evaluated the diagnostic performance of DTI parameters (MD, LD, RD, FA) in patients with cervical spondylotic myelopathy (CSM) who had spinal cord compression but no signal changes on conven...
KEY FINDING: FA values were negatively correlated with the degree of central canal stenosis, while RD values showed a positive correlation.