Browse the latest research summaries in the field of spinal disorders for spinal cord injury patients and caregivers.
Showing 61-70 of 104 results
J. Clin. Med., 2025 • January 9, 2025
Posterior vertebral resection techniques offer significant promise in the correction of pediatric spinal deformities. Careful case-by-case evaluation is necessary, especially because of the associated...
KEY FINDING: PVCR resulted in an average reduction in the Cobb angle from 86.3◦ preoperatively to 22.4◦ postoperatively, with a mean correction of 64%.
Cells, 2023 • August 28, 2023
This review comprehensively examines methodologies to induce the differentiation of MSCs into IVD cells for regenerative therapies for IDD, focusing on molecules, scaffolds, and environmental factors....
KEY FINDING: TGF-β superfamily members and GDF5 and 6 played key roles in MSC differentiation into NPC-like cells, with BMP-7 and GDF6 being potentially the most effective.
International Journal of Biological Sciences, 2024 • January 1, 2024
This study demonstrates the depletion of the selective autophagy receptor NBR1 in NPCs during the degeneration process, leading to the buildup of SRBD1 within NPCs, thereby accelerating NPCs senescenc...
KEY FINDING: NBR1 expression is downregulated in degenerative nucleus pulposus cells (NPCs) in human and rat models of intervertebral disc degeneration (IDD).
Eur Spine J, 2009 • February 12, 2009
The study evaluates the effectiveness of extensive cervical laminoplasty for spinal cord sarcoidosis combined with spondylotic changes. The results showed unsatisfactory operative outcomes and fluctua...
KEY FINDING: Operative outcomes following laminoplasty were not satisfactory in patients with spinal cord sarcoidosis combined with cervical spondylosis.
Front. Mol. Biosci., 2023 • July 14, 2023
The study explores gene signatures and immune cell infiltration related to IDD using bioinformatics analysis. Key findings include the identification of differentially expressed mRNAs, miRNAs, lncRNAs...
KEY FINDING: Identified 346 differentially expressed mRNAs, 12 differentially expressed miRNAs, 883 differentially expressed lncRNAs, and 916 differentially expressed circRNAs in the GEO database.
Neural Regeneration Research, 2013 • December 1, 2013
This study investigated the use of diffusion tensor imaging (DTI) to quantitatively measure pathological changes in a rat model of chronic cervical spondylotic myelopathy. A novel spongy polyurethane ...
KEY FINDING: The fractional anisotropy value gradually decreased over time (4 hours to 1 week) after spinal cord injury in the rat model.
Cells, 2022 • February 9, 2022
IVD degenerative disease is a major obstacle to independent and healthy living and an important issue that needs to be addressed and overcome. A number of studies have been performed on cell-based IVD...
KEY FINDING: Cell-based therapies, such as transplanting autologous NP-derived cells, are physiologically natural and avoid graft-versus-host reactions. However, harvesting autologous cells is invasive, and the cell yield is relatively low.
Annals of Translational Medicine, 2021 • May 1, 2021
This study investigates the correlations among lumbar sagittal balance parameters, inter-body cage positioning variables, and adjacent facet joint degeneration following transforaminal lumbar interbod...
KEY FINDING: Patients with AFD aggravation had significantly higher preoperative back pain VAS scores and postoperative ODI scores, indicating greater pain and disability.
Yonsei Med J, 2013 • May 1, 2013
This study aimed to determine the correlation between spinal fracture patterns (Denis classification) and neurologic recovery in surgically managed patients with thoracolumbar fractures and neurologic...
KEY FINDING: The common injuries making neurologic deterioration were burst fracture and fracture-dislocation.
Spinal Cord Series and Cases, 2019 • January 30, 2019
This case report describes an unusually early presentation of Charcot spinal arthropathy (CSA) in a 49-year-old male following a T4 ASIA A spinal cord injury (SCI). The patient developed CSA within 1 ...
KEY FINDING: The patient developed CSA within 1 year and 2 months of the initial spinal cord injury, which is significantly earlier than typically reported in the literature.