Arch Phys Med Rehabil, 2008 · DOI: · Published: April 1, 2008
This study investigated the relationship between how people with chronic spinal cord injury (SCI) move around and a marker of inflammation in their blood called C-reactive protein (CRP). CRP is linked to heart disease. The study found that people who use motorized wheelchairs tend to have higher CRP levels compared to those who use manual wheelchairs, walk with assistance, or walk independently. This suggests that mobility mode is related to inflammation levels. The researchers also found that obesity, a history of pressure ulcers, and urinary tract infections (UTIs) were associated with higher CRP levels in people with SCI.
CRP levels may be a useful marker for assessing cardiovascular risk in individuals with chronic SCI, similar to its use in the general population.
Interventions aimed at improving mobility, reducing obesity, and preventing infections (UTIs and pressure ulcers) may help reduce systemic inflammation and improve cardiovascular health in individuals with SCI.
Longitudinal studies are needed to investigate the relationship between changes in risk factors, CRP levels, and health outcomes in individuals with SCI.