Clinical Factors Associated with C - Reactive Protein in Chronic Spinal Cord Injury

Spinal Cord, 2017 · DOI: 10.1038/sc.2017.81 · Published: December 1, 2017

Spinal Cord Injury Cardiovascular Science Genetics

Simple Explanation

This study looked at factors that might be linked to higher levels of C-reactive protein (CRP) in people with long-term spinal cord injuries (SCI). CRP is a marker of inflammation in the body. The researchers found that things like having a higher BMI, using a urinary catheter, having a recent respiratory illness, and being of non-white race were all associated with higher CRP levels. Interestingly, the severity and location of the spinal cord injury itself didn't seem to be as important as these other factors when it came to CRP levels.

Study Duration

Between 8/2009 and 4/2015

Participants

338 individuals with chronic SCI

Evidence Level

Cross-sectional study

Key Findings

1
Greater BMI was associated with higher CRP levels, even when accounting for body fat distribution.
2
Urinary catheter use was significantly associated with elevated CRP, possibly due to chronic bacteriuria and pyuria.
3
Non-white race was independently associated with greater CRP levels in individuals with chronic SCI.

Research Summary

This study aimed to determine clinical factors associated with plasma C-reactive protein (CRP) in persons with chronic spinal cord injury (SCI). In multivariable models, factors associated with a higher CRP included a greater BMI, urinary catheter use, a respiratory illness in the past week, and non-white race. Clinical characteristics common in chronic SCI are associated with plasma CRP. These factors are more important than level and completeness of SCI and some are potentially modifiable.

Practical Implications

Targeted Interventions

Addressing modifiable factors like obesity, physical inactivity, and recurrent infections could lower cardiovascular disease risk in those with chronic SCI.

Further Research Needed

A longitudinal study is needed to assess the relationship between identified factors, chronic elevations in CRP, and subsequent cardiovascular health effects.

Clinical Monitoring

Regular monitoring of CRP levels and related clinical factors may help in early identification of individuals at higher cardiovascular risk.

Study Limitations

1
Reliance on self-report of current ulcer, UTI and of chronic medical conditions.
2
Cross-sectional design limits causal inferences.
3
Study population primarily male and white, limiting generalizability.

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