Efficacy and safety of different doses of azilsartan medoxomil in patients with hypertension A protocol of a network meta-analysis

Hypertension, characterized by elevated arterial pressure, poses a significant global public health challenge due to its association with cardiovascular and cerebrovascular diseases. The study aims to evaluate the efficacy and safety of different doses of azilsartan medoxomil in treating hypertension using a network meta-analysis. The network meta-analysis will utilize data from randomized controlled trials to compare different doses of azilsartan medoxomil against each other or a placebo.

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  This study will summarize all available data to provide reliable evidence of the value of different doses of azilsartan medoxomil for hypertension treatment.
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  The primary outcomes include 24-hour mean diastolic and systolic blood pressure, nighttime and daytime blood pressure, clinic blood pressure, and response rate.
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  Secondary outcomes are any adverse events, serious adverse events, and adverse events leading to treatment interruption.