Int. J. Mol. Sci., 2023 · DOI: 10.3390/ijms242115804 · Published: October 31, 2023
Researchers are looking for easier ways to create neurons for therapies and research, especially for canine models that mimic human nerve diseases. They've found that certain small molecules can change skin cells (fibroblasts) into cells with neuron-like characteristics, offering a potential shortcut compared to more complex methods. This study explored whether adult canine skin cells could be converted into neuron-like cells using a combination of small molecules. The goal was to see if this method could provide a practical source of neurons for studying and treating nerve damage in dogs, which often serve as models for human conditions. The research showed that while small molecules could indeed induce neuron-like features in canine skin cells, these changes were temporary. This means further work is needed to make the conversion more stable and useful for long-term therapies.
The study contributes to the development of cell replacement and transplantation therapies for nerve injuries, offering insights into converting readily available cells into neurons.
The induced neuronal features in ACDFs can be used to screen drugs targeting neurological disorders, providing a relevant model for canine-specific and potentially human-relevant drug responses.
The finding that neuronal induction is temporary highlights the need to overcome epigenetic and other barriers to achieve stable neuronal conversion, informing future research directions.