The Regenerative Potential of bFGF in Dental Pulp Repair and Regeneration

Regenerative endodontic therapy aims to use the body's natural healing processes to restore vitality and sensitivity to damaged pulp tissue caused by infection or trauma. Fibroblast growth factors, particularly bFGF, are key regulatory factors in pulp repair and regeneration, influencing cell behavior like migration, proliferation, and differentiation. This review explores the mechanisms of bFGF in dental pulp repair and regeneration and its potential therapeutic strategies for dental pulp-related clinical applications.

• 1
  bFGF acts through binding to tyrosine kinase FGF receptors on the cell membrane, triggering intracellular signaling pathways that initiate cell migration, proliferation, and differentiation.
• 2
  bFGF promotes cell proliferation and controls cell cycle progression by stimulating the expression of related genes and proteins, making it useful for amplifying stem cell numbers for regenerative treatments.
• 3
  bFGF plays a crucial role in maintaining stem cells' stemness, which is vital for their clinical application in regenerative endodontics.