Treatment of at-level spinal cord injury pain with botulinum toxin A

This study investigates whether botulinum toxin A (BoNTA) injections can help reduce pain experienced at the level of spinal cord injury (SCI). This type of pain is often difficult to treat. Participants received either BoNTA or a placebo, and their pain levels were monitored. After a period, those who received the placebo then received BoNTA, and vice versa, to compare the effects. While the study's results didn't reach statistical significance, some participants reported reduced pain and improved quality of life after receiving BoNTA injections, suggesting it might be a potential treatment worth further investigation.

• 1
  A higher proportion of participants reported a marked change in average pain intensity from baseline to 8 and 12 weeks post-BoNTA vs. post-placebo (33% vs. 0%).
• 2
  At 2 and 4 weeks post-BoNTA, almost all participants reported some degree of reduced pain, while the same was not seen post-placebo (83% vs. 0%).
• 3
  More participants reported at least moderate improvements in QOL post-BoNTA vs. post-placebo at 2 (33% vs. 0%) and 4 (33% vs. 0%), 8 (17% vs. 0%), and 12 (33% vs. 0%) weeks