Browse the latest research summaries in the field of anesthesiology for spinal cord injury patients and caregivers.
Showing 21-29 of 29 results
Neural Regeneration Research, 2015 • November 1, 2015
The study aimed to determine if intrathecal propofol administration could protect the spinal cord from ischemia-induced damage. Rats pre-treated with intrathecal propofol (100 µg and 300 µg) showed im...
KEY FINDING: Pre-treatment with intrathecal propofol significantly decreased hind limb motor dysfunction in rats with ischemic spinal cord injury 24 hours after ischemia/reperfusion.
Neural Regeneration Research, 2017 • January 1, 2017
This study investigates the neuroprotective effects of propofol on the blood-spinal cord barrier (BSCB) after ischemia/reperfusion injury (IRI) in rabbits. Spinal cord IRI was induced by infrarenal ao...
KEY FINDING: Propofol decreased histological damage to the spinal cord, indicating a protective effect on the tissue structure after ischemia/reperfusion injury.
Neural Regeneration Research, 2017 • March 1, 2017
Anesthesiologists must understand the pathophysiology of acute cervical spinal cord injuries (CSCI) to prevent secondary injury and improve patient outcomes. This includes careful preoperative assessm...
KEY FINDING: Maintaining mean arterial blood pressure (MAP) at 85 to 90 mmHg in the first week following injury can improve spinal perfusion.
Annals of Medicine, 2024 • April 16, 2024
Complex regional pain syndrome (CRPS) is a debilitating and complex condition that places a significant physical, psychological and emotional burden upon afflicted patients necessitating multi-modal a...
KEY FINDING: CRPS can be classified into two main categories: type 1 and type 2, with type 2 resulting from nerve damage.
Cureus, 2025 • February 22, 2025
This retrospective study examined the impact of volatile anesthetics (desflurane vs. sevoflurane) on functional outcomes in cervical SCI patients undergoing upper extremity nerve transfer procedures. ...
KEY FINDING: The desflurane group had greater median motor strength than the sevoflurane group towards the final follow-up when the desflurane group had median motor strength of 3 [interquartile range (IQR): 1-4] and sevoflurane group had a median motor strength of 1 (IQR: 0-2.25); p=0.014.
Clinics, 2012 • November 1, 2012
This study highlights the anesthetic and perioperative management of five patients with high cervical spinal cord injury who underwent laparoscopic insertion of a diaphragmatic pacemaker. The procedur...
KEY FINDING: The diaphragmatic pacemaker placement was successful in all five patients who participated in the study.
Neurochemical Research, 2025 • March 17, 2025
The study examined the protective effect of DEX on remifentanil-induced hyperalgesia in rats. Remifentanil, while effective for pain relief, can paradoxically increase pain sensitivity. The findings i...
KEY FINDING: DEX administration reduced mechanical allodynia and thermal hyperalgesia in rats experiencing remifentanil-induced hyperalgesia (RIH).
Frontiers in Cellular Neuroscience, 2021 • December 15, 2021
This study confirms that a clinical concentration of general anesthetic sevoflurane increased the expression of inflammatory factors in microglia and activated the caspase-3 by upregulating ATPIF1 expr...
KEY FINDING: Sevoflurane upregulates the expression of ATPIF1 to induce inflammation and caspase-3 activation.
Regeneration, 2017 • January 1, 2017
This study investigated the applicability of propofol as an immersion anesthetic in axolotls, focusing on its effects on cardiovascular function, action potential propagation in the spinal cord, and g...
KEY FINDING: Propofol has significantly less cardiovascular effect than benzocaine and MS-222 when used as an anesthetic in axolotls.