Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 101-110 of 296 results
Stat Methods Med Res, 2020 • November 1, 2020
This paper develops cluster-weighted estimators of marginal proportions that remain unbiased under informativeness, and derives analogues of three popular tests for clustered categorical data: the one...
KEY FINDING: Cluster-weighted tests based on variance estimators constructed under the null hypothesis maintain size closest to nominal.
The Journal of Spinal Cord Medicine, 2017 • May 1, 2017
This study aimed to identify biomarkers associated with health-related quality of life (HRQL) in individuals with spinal cord injury (SCI). The results indicated that C-reactive protein (CRP) is assoc...
KEY FINDING: CRP levels were inversely correlated with the Mental Component Summary (MCS) of the SF-36 questionnaire, even after adjusting for confounders.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
Bioinformatics provides an opportunity to leverage collaborations to define and deliver Optimal Care for Spinal Cord Injury (SCI) patients. Large longitudinal datasets offer opportunities for combinin...
KEY FINDING: The development of large longitudinal datasets represents an unprecedented opportunity for combining data across fields.
JOURNAL OF NEUROTRAUMA, 2017 • February 1, 2017
The study found that HMGB1 is elevated systemically in persons with acute or chronic traumatic SCI. HMGB1 levels in acute SCI were significantly higher than in uninjured persons and more than two-fold...
KEY FINDING: HMGB1 levels are significantly elevated in individuals with acute SCI within 0-3 days and 4-7 days post-injury, compared to uninjured controls.
IEEE Trans Biomed Eng, 2015 • October 1, 2015
This paper introduces a novel algorithm which can automatically optimize multi-electrode array stimulation parameters. The methodology is based on a novel Gaussian Process Batch Upper Confidence Bound...
KEY FINDING: GP-BUCB successfully controlled spinal electrostimulation in 37 testing sessions, selecting 670 stimuli.
Oncotarget, 2016 • October 20, 2016
The goal of the research reported here was the identification of potential serological biomarkers associated with the GBS. To address this objective, a quantitative proteomics approach was used to cha...
KEY FINDING: The results showed that Piccolo, a protein that is essential in the maintenance of active zone structure, constitutes a potential serological correlate of recovery from GBS.
PLOS Computational Biology, 2015 • June 25, 2015
An agent-based model (ABM) of ischemia/reperfusion-induced inflammation and PU (the PUABM) was created, calibrated to serial images of post-SCI PU, and used to investigate potential treatments in sili...
KEY FINDING: Tissue-level features of the PUABM recapitulated visual patterns of ulcer formation in individuals with SCI.
Spinal Cord Series and Cases, 2016 • September 29, 2016
This correspondence addresses methodological concerns about using Kappa statistics to assess the reliability of the International Spinal Cord Injury Musculoskeletal Basic Data Set (ISCIMSBDS). The aut...
KEY FINDING: The study defends the use of Kappa statistics for dichotomous variables in the ISCIMSBDS reliability study.
IEEE Trans Neural Syst Rehabil Eng, 2017 • October 1, 2017
This study investigates the use of human-generated rewards to train reinforcement learning (RL) controllers for functional electrical stimulation (FES) of arm movements in individuals with spinal cord...
KEY FINDING: RL controllers trained with human and pseudo-human rewards significantly outperformed standard controllers in reaching tasks.
JOURNAL OF NEUROTRAUMA, 2010 • January 1, 2010
This study used proteomic and phosphoproteomic analyses to characterize changes in protein expression and phosphorylation in the soluble fraction of rat spinal cords 24 hours after a contusion injury....
KEY FINDING: Several blood-related proteins were found only in injured tissue or were highly upregulated, indicating vascular damage after SCI.