Bioinformatics Research

KEY FINDING: There is a marked downregulation of natural killer cell genes in individuals with chronic SCI.

KEY FINDING: Individuals with SCI levels rostral to T5, where sympathetic nervous system disruption would occur, had more differentially expressed genes (N = 2226) compared to able-bodied participants.

KEY FINDING: Tau protein levels in serum and CSF increased rapidly after SCI, peaking at 12 hours.

KEY FINDING: A total of 1676 differentially expressed circRNAs were found in spinal cord 3 days after contusion. 1261 circRNAs were significantly downregulated, whereas the remaining 415 were significantly upregulated.

KEY FINDING: A total of 664 DEGs in the sham group and SCI groups at days 1, 3, and 7 following injury were identified in trkB.T1 KO mice.

KEY FINDING: A deep learning-based model can accurately identify differentiated cell types from brightfield images of NSCs as early as 1 day of culture.

KEY FINDING: Patients with SCI exhibit either M1-dominant or M2-dominant circulating monocytes (MOs), which are distinct from uninjured controls.

KEY FINDING: RNA-Seq technology improves the ability to understand gene expression network regulation, because it can identify isoform-specific gene regulators. This allows defining precise transcription start sites and 3' untranslated regions for each differentially expressed isoform.

KEY FINDING: Approximately 66 DEGs were identified in GSE45550 between 3–14 days after SCI, whereas 2418 DEGs were identified in GSE45006 1–56 days after SCI.

KEY FINDING: CRMP2KI suppresses somatic atrophy in sensorimotor cortex after spinal cord injury