Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 141-150 of 296 results
Front. Neurosci., 2022 • November 23, 2022
This study integrated transcriptomic and metabolomic data to investigate metabolic dysregulation in the acute phase of spinal cord injury (SCI) in rats. The researchers aimed to identify potential mol...
KEY FINDING: Histological analysis showed significant alterations in the microenvironment of the spinal cord after acute SCI, including poorly demarcated gray and white matter, cavities, and necrotic tissues. Locomotor function was also significantly reduced in rats with SCI.
MOLECULAR MEDICINE REPORTS, 2015 • April 24, 2015
The present study aimed to explore potential biomarkers and molecular mechanisms underlying SCI using bioinformatic methods. DEGs were shown to be enriched in pathways associated with immune response,...
KEY FINDING: The number of DEGs decreased in a time‑dependent manner following SCI, suggesting a changing molecular environment as time progresses after the injury.
Oxidative Medicine and Cellular Longevity, 2023 • January 12, 2023
This study aimed to identify specific molecular mechanisms in acute SCI patients compared to trauma controls by analyzing RNA-seq datasets and identifying differentially expressed genes (DEGs). The an...
KEY FINDING: A total of 64 specific genes were identified as the intersection of upregulated genes of the spinal cord and upregulated genes of human blood samples in SCI patients compared to trauma controls.
Frontiers in Immunology, 2023 • January 19, 2023
This study combined bulk RNA-seq and scRNA-seq data to investigate the immune landscape in the subacute phase of spinal cord injury (SCI). The research identified key immune hub genes (B2m, Itgb5, Vav...
KEY FINDING: B2m, Itgb5, and Vav1 were identified as key immune genes in macrophages/microglia during the subacute phase of SCI.
Not specified, 2023 • February 21, 2023
This study uses patch-based single-cell RNA sequencing to investigate the transcriptomic profiles of regenerating versus non-regenerating corticospinal tract (CST) neurons following PTEN and SOCS3 del...
KEY FINDING: Mitochondrial activities are heavily involved in CST regeneration, with genes related to ATP metabolism and oxidative phosphorylation being overexpressed in regenerating neurons.
BMC Medical Genomics, 2023 • March 1, 2023
This study investigated the role of immune cell infiltration in the hippocampus of Alzheimer's disease (AD) patients and identified key genes associated with AD pathogenesis. Transcriptomic data analy...
KEY FINDING: The relative abundance of immune cells in the hippocampus of AD patients was altered compared to healthy individuals.
Frontiers in Immunology, 2023 • March 29, 2023
This study systematically investigates changes in peripheral blood immune cells and differential expression of immune-related genes after SCI to identify immunodiagnostic biomarkers for SCI and for AI...
KEY FINDING: Seventeen kinds of immune cells showed different levels in SCI patients versus healthy controls, with seven immune cell types significantly increased after SCI.
BMC Genomics, 2023 • April 5, 2023
This study presents a high-quality genome of Whitmania pigra, and reports a transcriptome covering the starting point of cell differentiation to individual maturation. We described the whole process o...
KEY FINDING: Five broad stages of embryogenesis were defined: cleavage stages, blastocyst stage, gastrula stage, organogenesis and refinement, juvenile.
Frontiers in Cellular Neuroscience, 2023 • April 20, 2023
Reactive astrogliosis is a response of astrocytes to CNS disturbances, altering their numbers, morphology, and function. Single-cell transcriptomics highlights the heterogeneity of reactive astrocytes...
KEY FINDING: Single-cell transcriptomics has revealed remarkable heterogeneity of reactive astrocytes, indicating their multifaceted functions in a whole spectrum of neuropathologies, with important temporal and spatial resolution, both in the brain and in the spinal cord.
Neural Regeneration Research, 2023 • December 1, 2023
This research explores the transcriptomic changes during spinal cord regeneration in Cynops orientalis following injury, identifying differentially expressed genes at acute (4 days) and subacute (7 da...
KEY FINDING: 13,059 genes were differentially expressed during C. orientalis spinal cord regeneration compared with uninjured animals, with 4273 continuously down-regulated and 1564 continuously up-regulated.