Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 131-140 of 296 results
Front. Cell Dev. Biol., 2021 • October 11, 2021
This study used bioinformatics analysis to identify key eRNAs involved in spinal cord injury (SCI). The analysis revealed a regulatory network of transcription factors, eRNAs, target genes, immune ce...
KEY FINDING: Identified 21 DETFs, 24 DEeRNAs, and 829 DETGs in SCI patients compared to healthy controls.
International Journal of Medical Sciences, 2022 • January 1, 2022
This study investigates the role of immune cells and genes in Alzheimer's Disease (AD) by analyzing transcriptomic data from the prefrontal cortex of AD patients and healthy controls. The analysis rev...
KEY FINDING: Immune infiltration in the prefrontal cortex of AD patients differs from healthy samples, highlighting alterations in the brain's immune environment during AD.
BMC Genomics, 2022 • January 3, 2022
This study investigated DNA methylation changes in regenerative and non-regenerative regions of the Xenopus CNS after injury. The study found that DNA methylation patterns differ significantly between...
KEY FINDING: DNA from regenerative CNS (tadpole hindbrain, frog eye) was less methylated than non-regenerative CNS (frog hindbrain).
Adv Healthc Mater, 2022 • May 1, 2022
The study addresses the thermal instability of ChABC, which limits its therapeutic use for CNS injuries. Machine learning was used to design copolymers that stabilize ChABC in aCSF, with promising res...
KEY FINDING: Active machine learning identified copolymers that significantly improved ChABC's thermal stability.
J. Pers. Med., 2022 • March 22, 2022
The present review focuses on key advances in machine and deep learning, allowing for multi-perspective pattern recognition across the entire information set of patients in spine surgery. This is the ...
KEY FINDING: The review focuses on key advances in machine and deep learning, allowing for multi-perspective pattern recognition across the entire information set of patients in spine surgery.
iScience, 2022 • August 19, 2022
Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed 24 TSPAN family genes i...
KEY FINDING: TSPAN3-6, TSPAN9-11, TSPAN13-15, TSPAN17, TSPAN31, TSPAN33 are mainly upregulated, and TSPAN2, TSPAN7 are mainly downregulated.
Frontiers in Psychiatry, 2022 • August 23, 2022
This study used integrated co-expression network analysis to identify tissue-specific gene modules and functions in major depressive disorder (MDD) and bipolar disorder (BP). The analysis revealed nin...
KEY FINDING: Nine tissue-specific modules were identified in MDD across four tissues, and six modules in BP.
Acta Neuropathologica, 2022 • September 16, 2022
The study generated an integrated cell type-specific transcriptomic atlas of MS pathology spanning three major CNS sites including leukocortical, cerebellar and spinal cord areas. The study identified...
KEY FINDING: While we found strong cross-regional diversity among glial subtypes in control tissue, regional signatures become more obscure in MS.
Genomics Proteomics Bioinformatics, 2022 • September 29, 2022
The study introduces DrSim, a learning-based framework designed to infer similarity between transcriptional profiles for phenotypic drug discovery, addressing limitations of traditional unsupervised m...
KEY FINDING: DrSim outperforms existing methods in drug annotation, showing higher accuracy in predicting the mechanisms of action (MOAs) of compounds.
Neurospine, 2022 • September 1, 2022
This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal su...
KEY FINDING: GV-EA treatment regulated the expression of 173 mRNA, 260 lncRNA, and 153 circRNA genes altered by SCI.