Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 241-250 of 334 results
Nutrients, 2022 • November 5, 2022
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Higher serum levels of propionic acid, a short-...
KEY FINDING: Higher serum levels of propionic acid were associated with increased odds of cognitive decline.
Front. Neurosci., 2022 • November 23, 2022
This study integrated transcriptomic and metabolomic data to investigate metabolic dysregulation in the acute phase of spinal cord injury (SCI) in rats. The researchers aimed to identify potential mol...
KEY FINDING: Histological analysis showed significant alterations in the microenvironment of the spinal cord after acute SCI, including poorly demarcated gray and white matter, cavities, and necrotic tissues. Locomotor function was also significantly reduced in rats with SCI.
Frontiers in Bioengineering and Biotechnology, 2022 • December 5, 2022
The study aimed to explore a new microRNA (miRNA) which can bind to combining engineered exosomes for treatment of older OS patients. MiR-449a is down-regulated in osteosarcoma and suppresses cell pro...
KEY FINDING: MiR-449a is down-regulated in osteosarcoma and suppresses cell proliferation by targeting CCNB1.
Nature Communications, 2022 • December 15, 2022
The study introduces nanoHiMe-seq, a nanopore-sequencing-based method for interrogating the genome-wide localization of histone modifications and DNA methylation from single DNA molecules. nanoHiMe-se...
KEY FINDING: nanoHiMe-seq allows for the simultaneous profiling of CpG methylation and histone modifications, exhibiting utility, robustness, and sensitivity.
Data in Brief, 2023 • February 1, 2023
This data article presents RNA-seq data from a study investigating the effects of baclofen treatment on the spinal cord after a compression injury in mice. The data includes raw sequencing reads and b...
KEY FINDING: The study identified 992 differentially expressed genes in the spinal cord after baclofen treatment compared to a control group. This suggests that baclofen has a significant impact on gene expression following SCI.
MOLECULAR MEDICINE REPORTS, 2015 • April 24, 2015
The present study aimed to explore potential biomarkers and molecular mechanisms underlying SCI using bioinformatic methods. DEGs were shown to be enriched in pathways associated with immune response,...
KEY FINDING: The number of DEGs decreased in a time‑dependent manner following SCI, suggesting a changing molecular environment as time progresses after the injury.
Oxidative Medicine and Cellular Longevity, 2023 • January 12, 2023
This study aimed to identify specific molecular mechanisms in acute SCI patients compared to trauma controls by analyzing RNA-seq datasets and identifying differentially expressed genes (DEGs). The an...
KEY FINDING: A total of 64 specific genes were identified as the intersection of upregulated genes of the spinal cord and upregulated genes of human blood samples in SCI patients compared to trauma controls.
Frontiers in Immunology, 2023 • January 19, 2023
This study combined bulk RNA-seq and scRNA-seq data to investigate the immune landscape in the subacute phase of spinal cord injury (SCI). The research identified key immune hub genes (B2m, Itgb5, Vav...
KEY FINDING: B2m, Itgb5, and Vav1 were identified as key immune genes in macrophages/microglia during the subacute phase of SCI.
Not specified, 2023 • February 21, 2023
This study uses patch-based single-cell RNA sequencing to investigate the transcriptomic profiles of regenerating versus non-regenerating corticospinal tract (CST) neurons following PTEN and SOCS3 del...
KEY FINDING: Mitochondrial activities are heavily involved in CST regeneration, with genes related to ATP metabolism and oxidative phosphorylation being overexpressed in regenerating neurons.
BMC Medical Genomics, 2023 • March 1, 2023
This study investigated the role of immune cell infiltration in the hippocampus of Alzheimer's disease (AD) patients and identified key genes associated with AD pathogenesis. Transcriptomic data analy...
KEY FINDING: The relative abundance of immune cells in the hippocampus of AD patients was altered compared to healthy individuals.