Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 71-80 of 296 results
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
This study investigated the potential of muscle-based and circulatory biomarkers, specifically fatty metabolites and inflammatory cytokines, to predict pressure injury (PrI) recurrence in individuals ...
KEY FINDING: Gluteal intramuscular adipose tissue (IMAT) was greater than 15% in most Group II (83%) individuals, indicating a potential link between muscle quality and PrI recurrence.
Scientific Reports, 2019 • November 18, 2019
The study refines CMAP and MUNE methods for assessing spinal motor unit input in rat forelimbs and hindlimbs, demonstrating robustness and alignment with anatomical LMN counts. Validation in SOD1 muta...
KEY FINDING: CMAP and MUNE recordings are robust with low coefficients of variability in both forelimb and hindlimb of rats.
BMC Genomics, 2019 • November 8, 2019
This study aimed to elucidate the effect of α-Syn knockdown on transcriptional levels after SCI and to determine the mechanisms underlying α-Syn activity based on RNA-seq. RNA-seq analysis revealed 33...
KEY FINDING: Knockdown of α-Syn after SCI enhance motor function.
Neuromodulation, 2021 • January 1, 2021
This study investigates the impact of spinal cord stimulation (SCS) on protein expression in the spinal cord of rats with neuropathic pain. The results showed that SCS leads to a significant improveme...
KEY FINDING: SCS significantly improved mechanical sensitivity in animals with neuropathic pain after 48 hours of therapy.
J Transl Med, 2020 • March 14, 2020
This study assessed factors associated with circulating PAMM levels in adults with acute, traumatic SCI and in adults without SCI. Factors associated with PAMM levels varied based on the presence or a...
KEY FINDING: Participants with motor complete SCI showed the greatest change in PAMM levels compared to able-bodied individuals, with a statistically significant difference.
Data in brief, 2020 • December 31, 2019
This data article describes RNA sequencing data for detecting chronic transcriptomic changes in the rat soleus after SCI at two levels of injury severity, under conditions of restricted in-cage activi...
KEY FINDING: The sequenced data demonstrates good quality with a high alignment rate to the Rattus norvegicus reference assembly (Rn6).
BMC Medical Research Methodology, 2020 • May 7, 2020
The paper introduces baseline-adjusted proportional odds models for analyzing ordinal outcomes in clinical trials, addressing limitations of conventional methods. A simulation study demonstrated the s...
KEY FINDING: The simulation study demonstrated that the statistical power of the novel method was greater than that of conventional methods.
Bioelectronic Medicine, 2020 • April 8, 2020
Computational models have significantly impacted neurostimulation, aiding in pain and movement recovery, deep brain stimulation, and device regulations. These models serve as virtual testing platforms...
KEY FINDING: Computational models have improved the understanding of direct neuromodulatory effects of deep brain stimulation (DBS), suggesting that DBS provides symptom relief by creating an informational lesion in the brain.
Molecular Pain, 2020 • January 1, 2020
The study investigates the effects of different spinal cord stimulation (SCS) techniques on cell-specific transcriptomes in a rat model of neuropathic pain. It compares differential target multiplexed...
KEY FINDING: DTMP yielded strong and significant correlations to expression levels found in the healthy animals across every evaluated cell-specific transcriptome.
Journal of Personalized Medicine, 2020 • October 21, 2020
This study used a proteomic approach to understand the molecular mechanisms of COVID-19 infections in spinal cord injury (SCI) patients, aiming to identify biomarkers and potential therapeutic options...
KEY FINDING: Differentially expressed proteins were identified in SCI patients with COVID-19, with 20 proteins upregulated and 13 downregulated.