Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,641-1,650 of 1,651 results
Stem Cell Research & Therapy, 2020 • April 23, 2020
This study investigates the role of hepatocyte growth factor (HGF) in mesenchymal stem cell (MSC)-induced recovery in spinal cord injured (SCI) rats. The researchers found that MSCs promote neurologic...
KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.
Cell Adhesion & Migration, 2012 • November 1, 2012
Two recent studies show that activating integrin signaling in dorsal root ganglion (DRG) neurons renders them able to overcome inhibitory signals, and could possibly lead to new strategies to improve ...
KEY FINDING: Addition of CSPGs to dorsal root ganglion (DRG) cultures resulted in a reduction of activated integrins and growth inhibition. By adding manganese to the cultures, both FAK phosphorylation and growth response was restored, indicating that integrin activation is sufficient to override the inhibitory effects of CSPGs.
Neural Regeneration Research, 2023 • March 31, 2023
This study demonstrated the neuroprotective role of Rheb in promoting axon regeneration and increasing RGC survival after ONC. Overexpression of caRheb in RGCs activated the mTORC1 pathway, leading to...
KEY FINDING: Overexpression of constitutively active Rheb promoted survival of retinal ganglion cells in the acute (14 days) and chronic (21 and 42 days) stages of injury.
Molecular Neurobiology, 2020 • August 30, 2019
This study investigates the regulation of CNS-specific PPARGC1A transcripts in human neuronal cell lines and a rat model of ischemia. The findings reveal that a GT repeat polymorphism and hypoxia infl...
KEY FINDING: A naturally occurring variable GT repeat polymorphism increases promoter activity in neuronal cell lines.
Nature Communications, 2023 • March 3, 2023
This study elucidates how histone H2A monoubiquitination (H2Aub1) is targeted to specific genomic locations in Arabidopsis by cohesin subunits. The findings demonstrate that AtSYN4 interacts with AtSC...
KEY FINDING: The Arabidopsis cohesin subunits AtSYN4 and AtSCC3 interact with each other, and AtSCC3 binds to AtBMI1s.
JBC, 2012 • May 18, 2012
The neural cell adhesion molecule L1 plays crucial roles during development of the nervous system, such as neuronal migration and survival, axon outgrowth and fasciculation, and myelination, but it is...
KEY FINDING: L1 stimulation leads to the generation of a 70-kDa transmembrane fragment that is translocated to the nucleus.
JCI Insight, 2021 • April 8, 2021
This study identifies Itga7-expressing muscle-resident glial cells that are activated by loss of neuromuscular junction (NMJ) integrity. Upon activation, muscle glial–derived progenies expressed neuro...
KEY FINDING: Muscle-resident glial cells, identified by Itga7 expression, are activated by nerve injury and express neurotrophic genes like Ngfr, Tnc and Gdnf.
eLife, 2020 • October 6, 2020
The study uses optogenetic systems, optoRaf and optoAKT, to delineate the contribution of the ERK and AKT signaling pathways to neuroregeneration in live Drosophila larvae. optoRaf or optoAKT activati...
KEY FINDING: OptoRaf or optoAKT activation enhanced axon regeneration in both regeneration-competent and -incompetent sensory neurons in the peripheral nervous system.
Biochem Biophys Res Commun, 2018 • February 19, 2018
This study investigates the role of Wnt/β-catenin signaling in fibrotic scar formation following spinal cord injury (SCI) in adult mice using a compression-SCI model and TOPgal reporter mice. The resu...
KEY FINDING: Wnt/β-catenin signaling reporter TOPgal positive cells appeared at the lesion site by 5 days, peaked on 7 days, and diminished by 14 days post injury.
Scientific Reports, 2019 • January 17, 2019
We considered SCI-induced inflammatory mediators as a type of toxin that inhibits the regeneration of injured tissue/cells, and we identified the associated genes and interacting proteins from known b...
KEY FINDING: Tumor necrosis factor (TNF) had the highest scores, and the top 30 were adopted as core data.