Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,631-1,640 of 1,651 results
Cells, 2021 • September 5, 2021
Human iPSCs have become a powerful tool in basic as well as translational and clinical research because of their ability to be maintained indefinitely whilst preserving the genetic makeup of the host. ...
KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).
npj Regenerative Medicine, 2022 • January 1, 2022
This review summarizes the role of the Hippo pathway in zebrafish regeneration, noting that Yap1/Taz signaling often enhances regeneration through promoting cell proliferation, progenitor cell dediffer...
KEY FINDING: Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration, suggesting therapeutic potential in promoting YAP/TAZ signaling to enhance mammalian regeneration.
PNAS, 2022 • February 24, 2022
The study characterizes the landscape of m5C mRNA modifications in Plasmodium parasites, revealing higher levels in gametocytes. It identifies NSUN2 as a major mRNA m5C methyltransferase. Knockout of ...
KEY FINDING: m5C mRNA methylation is strikingly enhanced in the transcriptomes of gametocytes in both Plasmodium yoelii and Plasmodium falciparum.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • June 21, 2013
This study aimed to understand how HMGB1, a protein known to mediate inflammation in mammalian spinal cord injuries, functions in animals capable of spontaneous spinal cord regeneration, specifically ...
KEY FINDING: Gecko HMGB1 paralogs (gHMGB1a and gHMGB1b) exhibit differential responses to spinal cord trauma and inflammatory challenges, with gHMGB1b significantly upregulated in the injured cord.
Scientific Reports, 2017 • September 18, 2017
This study demonstrates that α-SNAP is enriched in ovarian granulosa cells and plays a crucial role in folliculogenesis. The hyh mutation of α-SNAP leads to increased granulosa cell apoptosis, prematu...
KEY FINDING: α-SNAP protein is highly expressed in granulosa cells (GCs) of ovarian follicles, and its expression is modulated by gonadotropin stimuli.
SMALL GTPASES, 2020 • January 1, 2020
Adult CNS axons fail to regenerate after injury due to extrinsic inhibitory factors and a low intrinsic capacity for axon growth, unlike developing neurons. ARF6 and Rab11, small GTPases, regulate pol...
KEY FINDING: ARF6 activation prevents the axonal transport of integrins in Rab11 endosomes in mature CNS axons, restricting them to the somato-dendritic domain.
Neural Regeneration Research, 2015 • December 1, 2015
This study investigated the effects of transplanting human telomerase reverse transcriptase (hTERT) gene-transfected Schwann cells into a rat model of spinal cord injury (SCI). The results demonstrate...
KEY FINDING: Transplantation of hTERT gene-transfected Schwann cells improved motor function in SCI rats between 1 and 4 weeks after model establishment.
Journal of Clinical Orthopaedics and Trauma, 2022 • January 4, 2022
The Wnt/mTOR signaling pathway is a ubiquitous signaling cascade involved in various physiological and pathological processes, including those related to spinal cord injury (SCI). It plays a crucial r...
KEY FINDING: Wnt signaling plays an important role in SCI, regulating neural stem cell proliferation and differentiation, axon regeneration, neuroinflammation, and pain.
BMC Developmental Biology, 2007 • May 24, 2007
This study investigates the regeneration of neural crest derivatives, specifically melanophores and spinal ganglia, in the Xenopus tadpole tail after amputation. The findings indicate that melanophore...
KEY FINDING: Cells do not emigrate from the spinal cord during tail regeneration, indicating that a new neural crest is not induced as in embryonic development.
Journal of Orthopaedic Research, 2020 • June 25, 2019
This study aimed to identify risk factors contributing to the degeneration of rotator cuff tendons, specifically the subscapularis (SSC) tendon, by analyzing tissue samples from patients undergoing ar...
KEY FINDING: Patient age significantly correlates with the expression of MMP-2 and RUNX2 genes in the subscapularis tendon.