Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 31-40 of 1,651 results
Journal of Orthopaedic Surgery and Research, 2023 • September 13, 2023
This research investigates the role of microglia and ferroptosis in spinal cord injury (SCI) using single-cell RNA sequencing data from mice at 3 and 14 days post-injury. The study identifies key gene...
KEY FINDING: Microglia are associated with immune system regulation at different time points after SCI and can modulate cytokine production.
Regenerative Therapy, 2023 • March 31, 2023
This study demonstrates that Tanshinone IIA (TSIIA) protects motor neuron-like NSC-34 cells from lipopolysaccharide (LPS)-induced cell injury. The protective effect of TSIIA is mediated by the regulat...
KEY FINDING: TSIIA alleviates cell injury induced by LPS and increases TCTN2 expression in LPS-exposed NSC-34 cells.
Curr. Issues Mol. Biol., 2023 • September 13, 2023
The study aimed to identify transcriptome changes in the acute phase of SCI and the effect of Tamoxifen on those changes in a rat model of SCI. Results showed differential expression of genes related ...
KEY FINDING: SCI induces differential expression of 708 genes, with enriched pathways related to the SCI pathway and inflammatory response.
Int. J. Mol. Sci., 2023 • September 5, 2023
This study investigates the germinal origin of salivary and lacrimal glands using transgenic TRiCK mice, revealing that these glands contain cells derived from all three germ layers: neuroectoderm, me...
KEY FINDING: Salivary and lacrimal glands contain cells derived from all three germ layers (ectoderm, mesoderm, and endoderm).
Neural Regeneration Research, 2024 • September 22, 2023
This study demonstrates that myelin debris induces lipid droplet accumulation in perilesional neurons after spinal cord injury (SCI), leading to lipotoxic damage and neuronal death. The study identifi...
KEY FINDING: Lipid droplets accumulate in perilesional spinal cord neurons after spinal cord injury in mice, induced by myelin debris.
NEURAL REGENERATION RESEARCH, 2024 • September 22, 2023
This study provides an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identifies sexual dimorphisms in terms of cytokine levels, and determines local cytokines t...
KEY FINDING: Pro-inflammatory cytokines like TNFα, IL-1β, and IL-6 are upregulated after SCI but return to normal levels within approximately 24 hours.
Scientific Reports, 2023 • November 14, 2023
This study investigated the effects of 4-methylumbelliferone (4-MU), an inhibitor of hyaluronan synthesis, on glial scar formation and functional recovery after spinal cord injury (SCI) in rats. Rats ...
KEY FINDING: A low dose of 4-MU (1.2 g/kg/day) reduced hyaluronan and chondroitin sulfate levels in uninjured spinal cords.
The Journal of Neuroscience, 2024 • January 3, 2024
This study investigates the role of astrocytic Rac1 in the development of hyperreflexia and spasticity following spinal cord injury (SCI) in mice. The researchers found that conditional knockout of Ra...
KEY FINDING: Astrocytic Rac1KO reduced SCI-related H-reflex hyperexcitability, indicating less spasticity.
Inflammation, 2024 • April 1, 2024
This study investigates the therapeutic potential of GlyNAC (glycine and N-acetylcysteine) in treating spinal cord injury (SCI) by reducing oxidative stress and skeletal muscle atrophy in a rat model....
KEY FINDING: GlyNAC treatment significantly elevated BBB scores from the first to the eighth week after intervention, suggesting improved motor function recovery in rats with SCI.
Frontiers in Immunology, 2023 • November 8, 2023
This study investigates the impact of zinc status on spinal cord injury (SCI) pathology in mice, revealing that zinc deficiency exacerbates inflammation and impairs axonal regeneration, leading to wor...
KEY FINDING: Zinc deficiency after SCI promotes the translocation of NF-kB in macrophages, leading to a pro-inflammatory phenotype and increased expression of pro-inflammatory cytokines.