Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 41-50 of 1,651 results
Molecular Pain, 2024 • January 1, 2024
This study investigates the therapeutic effects of Kilohertz High Frequency Electrical Stimulation (KHES) on neuropathic pain in mice, focusing on the TRPV1/NMDAR2B signaling pathway. The results demo...
KEY FINDING: KHES significantly alleviated mechanical and thermal allodynia in neuropathic pain mice, demonstrating its potential as a treatment.
npj Biofilms and Microbiomes, 2023 • December 4, 2023
This study investigates the relationship between spinal cord injury (SCI), gut dysbiosis, and neurological recovery, focusing on the role of short-chain fatty acids (SCFAs). The research involved anal...
KEY FINDING: SCI patients exhibited a decrease in SCFA-producing genera, such as Faecalibacterium, Megamonas, and Agathobacter, compared to healthy controls.
Heliyon, 2023 • November 27, 2023
This review elucidates the inflammatory response to SCI, focusing on the infiltration of immune cells, specifically macrophages. It examines their phenotype and provides an explanation of their polari...
KEY FINDING: M1 macrophages exacerbate inflammation and hinder neuronal regeneration in SCI, whereas M2 macrophages mitigate inflammation and foster axonal growth and functional recovery.
Int. J. Mol. Sci., 2023 • December 10, 2023
This review explores the potential of Schwann cell-derived exosomal vesicles (SCEVs) as a therapy for spinal cord injury (SCI). SCEVs offer advantages over cell-based therapies, including safety, stab...
KEY FINDING: SCEVs can promote axon regeneration in vitro and in vivo following PNI.
Front. Cell. Neurosci., 2023 • December 14, 2023
This study investigated the neuroprotective effects of nicotinamide mononucleotide (NMN) on spinal cord injury (SCI) in mice using RNA sequencing and qRT-PCR analysis. The results demonstrated that NM...
KEY FINDING: NMN supplementation restores NAD+ levels after SCI, promoted motor function recovery, and alleviated pain in a mouse model.
Journal of Orthopaedic Surgery and Research, 2024 • January 9, 2024
This study aimed to investigate the action of circ_0006640 transferred by MSC-exosomes on functional recovery after SCI. The results showed that circ_0006640 overexpression protected microglial cells ...
KEY FINDING: Circ_0006640 expression is decreased in SCI mice and LPS-induced microglial cells, suggesting its involvement in SCI pathology.
Surgical Neurology International, 2023 • December 13, 2023
This study demonstrates the potential of Neuro-PEG, a PEG-chitosan conjugate, to induce sensorimotor recovery in swine after complete spinal cord transection. The experimental group treated with Neuro...
KEY FINDING: Neuro-PEG treatment led to the recovery of motor function in pigs after complete spinal cord transection.
Heliyon, 2024 • December 21, 2023
This study investigated the effects of electrical stimulation (ES) on spinal cord injury (SCI) in rats using transcriptomic and proteomic sequencing to understand the underlying mechanisms. The result...
KEY FINDING: ES (0.5 mA, 0.1 ms, 50 Hz) had a positive effect on motor dysfunction and neuronal regeneration in rats after SCI.
Cell Communication and Signaling, 2024 • January 1, 2024
This study demonstrated that H2S preserved spinal cord neuron loss, prevented motor dysfunction, reduced inflammatory responses and microglial M1 polarization, and exerted neuroprotective effects via ...
KEY FINDING: H2S ameliorated spinal cord neuron loss, prevented motor dysfunction after SCIRI, and exerted a neuroprotective effect via the inhibition of PANoptosis and overactivated microglia-mediated neuroinflammation in SCIRI.
Frontiers in Neurology, 2024 • January 5, 2024
This study analyzes the research hotspots, frontiers, and development trends in the field of cell death after SCI. The bibliometric analysis reveals publication patterns, collaborations, and research ...
KEY FINDING: Research on cell death after SCI has grown significantly over the past 23 years, with China and the United States being the main contributors.