Musculoskeletal Medicine Research
Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 261-270 of 278 results
Editorial: Advances in non-union diagnostics, therapy and the understanding of its pathogenesis: current concepts from bench to bedside
Frontiers in Surgery, 2023 • September 11, 2023
Failed fracture healing remains a significant complication, and ongoing research aims to improve understanding of contributing factors at local and systemic levels. The immune system's role in bone he...
KEY FINDING: Interferon-gamma (IFN-y) signaling plays a key role in orchestrating immunological functions and serves an anabolic function in osseous biology, leading to osteoblastic activation.
Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study
Frontiers in Physiology, 2023 • October 11, 2023
This study investigates the role of mechanical stimulation in heterotopic ossification (HOTL) using a mouse model with Enpp1 gene deficiency. The mice were subjected to spinal immobilization and tread...
KEY FINDING: Spinal immobilization effectively restricts the flexion and extension of cervical and thoracic vertebrae in mice, delaying spinal ligament ossification and reducing chronic secondary spinal cord injury.
Which Indicator Among Lumbar Vertebral Hounsfield Unit, Vertebral Bone Quality, or Dual-Energy X-Ray Absorptiometry-Measured Bone Mineral Density Is More Efficacious in Predicting Thoracolumbar Fragility Fractures?
Neurospine, 2023 • December 1, 2023
The study aimed to determine which indicator—lumbar vertebral Hounsfield units (HU), vertebral bone quality (VBQ), or bone mineral density (BMD)—is most effective in predicting thoracolumbar fragility...
KEY FINDING: Lumbar vertebral HU exhibited a positive correlation with BMD (p < 0.01).
Biomechanical Study of 3 Osteoconductive Materials Applied in Pedicle Augmentation and Revision for Osteoporotic Vertebrae: Allograft Bone Particles, Calcium Phosphate Cement, Demineralized Bone Matrix
Neurospine, 2023 • December 1, 2023
This study evaluated the biomechanical properties of pedicle screws augmented or revised with allograft bone particles (ABP), calcium phosphate cement (CPC), and demineralized bone matrix (DBM) in ost...
KEY FINDING: ABP, CPC, and DBM significantly enhanced biomechanical properties of the screws.
Theoretical and experimental study of attenuation in cancellous bone
Journal of Biomedical Optics, 2024 • March 19, 2024
This paper introduces the photoacoustic differential attenuation spectrum (PA-DAS) method to study the attenuation characteristics of cancellous bone for osteoporosis diagnosis. The method modifies Bi...
KEY FINDING: The photoacoustic differential attenuation spectrum (PA-DAS) method can effectively differentiate osteoporotic bone from healthy bone.
Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review
Vet. Sci., 2024 • April 26, 2024
Musculoskeletal injuries in sport horses pose significant challenges, often leading to performance losses and affecting the horse's overall well-being, with social and economic implications. A compreh...
KEY FINDING: Musculoskeletal injuries are prevalent in sport horses, impacting their ability to return to exercise. Equine medicine has rapidly developed diverse therapeutic options for these problems.
Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences
Skeletal Muscle, 2024 • May 13, 2024
The study investigates the impact of mouse strain, sex, and injury type on intramuscular fat (IMAT) formation, myofiber regeneration, and fibrosis. Results show that C57BL/6J mice are resistant to IMA...
KEY FINDING: Bl6 mice are more resistant to IMAT formation compared to 129S and CD1 strains.
Spiny mice are primed but fail to regenerate volumetric skeletal muscle loss injuries
Skeletal Muscle, 2024 • October 20, 2024
The study compared the regenerative response of Acomys and Mus to VML injuries in the tibialis anterior (TA) muscle. Contrary to expectations based on Acomys' regenerative capabilities in other tissue...
KEY FINDING: Neither Acomys nor Mus recovered lost muscle mass or myofiber number within three months following VML injury, and Acomys also failed to recover force production better than Mus.
3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration
Materials Today Bio, 2025 • January 27, 2025
This study successfully fabricated 3D-printed Ga-MBG/TCP scaffolds with interconnected porous structures and controlled gallium ion release. In vitro experiments demonstrated that the Ga-MBG/TCP compo...
KEY FINDING: The 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis.
Significantly increased bone volume in a critical-sized defect model in the rat animal model by transplantation of a stand-alone vascularized periosteal flap
European Journal of Trauma and Emergency Surgery, 2025 • January 11, 2025
This study investigates the use of periosteal flaps (PF) to enhance bone healing in non-unions, comparing a vascularized (pedicled) PF to a ligated PF and a control group in a rat femur model. The res...
KEY FINDING: The pedicled periosteal flap (PF) group showed a significantly higher bone volume compared to the other groups after 10 weeks.