Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 4,951-4,960 of 5,253 results
Brain Res, 2015 • September 4, 2015
The propriospinal system is important for normal spinal cord physiology as well as functional recovery after SCI in all mammals. Propriospinal neurons are the most promising targets for therapeutic in...
KEY FINDING: Propriospinal tracts (PSTs) possess greater innate regenerative capacity, and have been shown to strongly respond to PN/SC grafts.
J. Exp. Med., 2014 • May 5, 2014
This study investigates the role of B-RAF kinase in promoting axon growth and regeneration in both the peripheral and central nervous systems using conditional gain-of-function mouse models. The resea...
KEY FINDING: Conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo without upstream neurotrophin signaling.
eLife, 2023 • August 3, 2023
The present study showed that ALKBH5 plays a critical role in axonal regeneration after nerve injury. The ALKBH5 protein level was reduced in DRG neurons following SNC, which enhanced neurite outgrowt...
KEY FINDING: Knockdown of ALKBH5 enhanced sensory axonal regeneration, whereas overexpressing ALKBH5 impaired axonal regeneration in an m6A-dependent manner.
eNeuro, 2017 • August 11, 2017
The study demonstrates that stress and GCs enhance the sprouting and regenerative growth of adult sensory axons, both in vitro and in vivo, highlighting their role as modifiers of neuronal plasticity....
KEY FINDING: DRG sensory neurons express significantly higher levels of glucocorticoid receptors (GRs) compared to brain regions like the hippocampus.
Frontiers in Cellular Neuroscience, 2021 • December 15, 2021
This study confirms that a clinical concentration of general anesthetic sevoflurane increased the expression of inflammatory factors in microglia and activated the caspase-3 by upregulating ATPIF1 expr...
KEY FINDING: Sevoflurane upregulates the expression of ATPIF1 to induce inflammation and caspase-3 activation.
Frontiers in Neuroinformatics, 2019 • April 5, 2019
The project MEEGIPS, a Modular EEG Investigation and Processing System for visual and automated detection of HFOs, introduces a highly user friendly software that includes five of the most prominent au...
KEY FINDING: MEEGIPS is a highly user friendly software that includes five of the most prominent automated detection algorithms.
Neuroimage, 2009 • May 1, 2009
This study investigated the use of quantitative MRI techniques (qT2 and MTR) to assess demyelination and remyelination in a mouse model of multiple sclerosis. Lysolecithin was injected into the spinal...
KEY FINDING: The myelin water fraction (MWF) and geometric mean T2 value significantly decreased at 14 days post-injection, indicating demyelination. By 28 days, these values returned to control levels, suggesting remyelination.
Chinese Journal of Reparative and Reconstructive Surgery, 2018 • August 1, 2018
The review provides a historical overview of glial scar research in the context of spinal cord injury repair. It summarizes the conflicting views on the role of glial scars in nerve regeneration and f...
KEY FINDING: The traditional view of glial scars as physical barriers to nerve regeneration is being challenged.
The Journal of Neuroscience, 2014 • May 28, 2014
This study investigates the role of astrocyte GLT1 overexpression in a rat model of cervical spinal cord injury (SCI). The results showed that astrocyte-targeted GLT1 overexpression increased lesion s...
KEY FINDING: GLT1 expression in astrocytes decreases following cervical spinal cord injury in mice, persisting for at least 6 weeks.
Neurochem Res, 2016 • July 1, 2016
This is an erratum, correcting a previously published article. The correction involves adding grant information to the acknowledgment section. The original article investigates trophic factors after s...
KEY FINDING: The erratum itself does not present any new findings; it only adds grant information to the original article's acknowledgment section.