Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 4,961-4,970 of 5,253 results
International Journal of Molecular Sciences, 2020 • September 24, 2020
The study screened small organic compounds for their ability to mimic the HNK-1 carbohydrate, which is known to play a role in preferential motor reinnervation after nerve injury. Six compounds were i...
KEY FINDING: Six small organic compounds (ursolic acid, indirubin, tosufloxacin, 5-nonyloxytryptamine, hexachlorophene, and tamoxifen) were identified as HNK-1 mimetics using a competitive ELISA.
J Comp Neurol, 2016 • February 1, 2016
We examined whether there were changes in the number of different types of synapses during the development of chronic orofacial pain after CCI-ION. Our data indicate that trigeminal nerve injury leads...
KEY FINDING: Trigeminal nerve injury leads to an increase in R-synaptic profiles (presumably excitatory synapses) in lamina I of Vc/C2.
Frontiers in Robotics and AI, 2019 • August 21, 2019
This study investigated the impact of modulated task difficulty on learning a complex motor task using a rowing simulator. The experimental group, training with variable water density, showed potentia...
KEY FINDING: Both groups reduced error and variability, but the experimental group showed potential benefits for spatial consistency and velocity accuracy.
Biomaterials, 2014 • September 1, 2014
The study investigates the distinct roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes using a bone marrow chimera m...
KEY FINDING: There was no correlation between microglia populations and neuron populations at the microelectrode-tissue interface.
Behav Neurosci, 2011 • December 1, 2011
Estrous cycle disruption after SCI in female rats is a common phenomenon, and this study investigates whether it's due to the injury itself or the stress of surgery. The study found that both the spin...
KEY FINDING: Estrous cyclicality was disrupted in approximately 76%, 46%, and 50% of the rats after HX, EMG, and dye injection surgeries, respectively.
Glia, 2007 • May 1, 2007
This study examined the role of Myt1, a transcription factor, in oligodendrocyte regeneration and remyelination in both rodent and human CNS demyelinated lesions. The MHV model was used to induce spin...
KEY FINDING: The density of Myt1 expressing cells markedly increased in lesioned areas of spinal cord white matter in MHV-infected mice, peaking during early remyelination.
PLoS ONE, 2016 • August 25, 2016
This study compares three different dMRI protocols applied to investigate the microstructure of both gray (GM) and white matter (WM) in the lumbar region of the mouse spinal cord. The protocols were c...
KEY FINDING: Intermediate features (12 directions, b = 1200 s/mm2) provided the overall minimum inter- and intra-subject variability in most cases.
The Journal of Neuroscience, 1994 • June 1, 1994
This study investigated the central projections and functional properties of regenerated primary afferents in cats following peripheral axotomy and nerve regeneration. The researchers found that follo...
KEY FINDING: Regenerated proprioceptive afferents can evoke measurable monosynaptic CDPs, unlike controls, indicating a functional change after axotomy.
Cellular and Molecular Neurobiology, 2004 • June 1, 2004
This study used nestin and Fluoro-Jade B to study the regional differences between ischemic and IPC-induced changes of ependyma and the gray matter of rat lumbosacral spinal cord. The study demonstrat...
KEY FINDING: Twelve-minute ischemia induced nestin positivity in ependyma and reactive astrocytes at the L1−3 spinal cord segments. This identifies the L1-L3 region as viable after the ischemic event.
Neurological Research and Practice, 2019 • April 4, 2019
This study demonstrates a positive correlation between ulnar nerve CMAP amplitudes and AIS incompleteness over time in cervical SCI patients. Early ulnar nerve axonal integrity (within 4 weeks) is an ...
KEY FINDING: Higher ulnar nerve CMAP amplitudes are associated with better AIS grades over the entire follow-up period in cervical SCI patients.