Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,041-5,050 of 5,253 results
Neural Regen Res, 2025 • September 6, 2024
Olfactory receptors, traditionally recognized for their role in detecting volatile compounds, have been found to have broader functional implications in numerous non-olfactory tissues. Ectopic OR expr...
KEY FINDING: Olfactory receptors are crucial for detecting odors and influencing behaviors from food choices to emotional memories, and have potential applications in medical diagnostics and environmental monitoring.
Neural Regeneration Research, 2013 • January 1, 2013
Following spinal cord injury, numerous endogenous Schwann cells migrate into the lesion site from the nerve roots, involving in the formation of repaired tissue and myelination of regenerating and dem...
KEY FINDING: Following spinal cord injury, endogenous Schwann cells invade the lesion site, involving in tissue repair and axonal regeneration and myelination.
Int. J. Biol. Sci., 2019 • January 1, 2019
This study investigates the neuroprotective effects of icariin (ICA) on spinal cord injury (SCI) by attenuating endoplasmic reticulum (ER) stress through the PI3K/AKT signaling pathway. The results de...
KEY FINDING: ICA administration significantly enhanced motor recovery and protected spinal cord tissues against infraction and hemorrhage post injury.
Frontiers in Cellular Neuroscience, 2014 • December 10, 2014
The review discusses the influence of the nervous system on skeletal muscles and their atrophy, introducing the current state of knowledge regarding mechanisms by which the nervous system regulates sk...
KEY FINDING: Denervation-induced muscle atrophy is reduced in muscles lacking connexins 43 and 45, suggesting these channels play a key role in the atrophy process.
Annals of Rehabilitation Medicine, 2014 • August 1, 2014
This study aimed to determine the effect of combined cervical radiculopathy on the prognosis of patients with traumatic cervical spinal cord injury (SCI). The study found that a significant proportion...
KEY FINDING: Almost half (48.5%) of the cervical SCI patients also had cervical radiculopathy.
eLife, 2018 • October 2, 2018
This study uses an integrated systems biology approach to understand the molecular mechanisms underlying spinal cord injury (SCI) pathophysiology. Large-scale RNA-seq data from healthy subjects was le...
KEY FINDING: Systematic literature analysis identified 695 unique human genes associated with the response to SCI by small-scale experiments.
PNAS, 2000 • May 9, 2000
This study investigates how the brain reorganizes after a loss of sensory input from the arm in adult monkeys. The researchers found that nerve fibers from the face area of the brainstem grow into the...
KEY FINDING: After dorsal column lesions or arm amputation, face afferents from the trigeminal nucleus sprout and grow into the cuneate nucleus in adult monkeys.
Eur Spine J, 2011 • December 5, 2010
This study investigated the effect of cervical radiculopathy on the cutaneous silent period (CSP), an electrophysiological measure of spinal inhibitory reflexes. The results showed that the CSP is pre...
KEY FINDING: The cutaneous silent period (CSP) was preserved in most patients with cervical radiculopathy, regardless of which finger was stimulated.
Neurosci Bull, 2013 • August 1, 2013
Successful axonal regeneration in the injured nervous system is a complex process that involves coordinated regulation of gene expression in the soma and cytoskeleton assembly at the growth cone. The ...
KEY FINDING: A large-scale RNAi-based genetic screen has identified dual leucine zipper-bearing kinase 1 (DLK-1) as a key regulator of axon regeneration
Cells, 2022 • February 18, 2022
This study examined the response of astrocyte subpopulations to spinal cord injury (SCI) in mice. The researchers investigated whether SCI induces changes in astrocyte subpopulation distribution and e...
KEY FINDING: Astrocyte subpopulation distribution in the spinal cord did not change to a selectively synaptogenic phenotype following mouse cervical hemisection-type SCI.