Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,031-5,040 of 5,253 results
The Journal of Spinal Cord Medicine, 2018 • September 1, 2018
This study aimed to determine if a self-report measure of sacral function in chronic SCI patients accurately predicts sacral examination results. The study compared self-report survey results with sac...
KEY FINDING: Patients with complete injuries (AIS A) who reported no sacral motor/sensory function via survey were correct in relation to the sacral exam, showing 100% Negative Predictive Value (NPV).
Glia, 2019 • November 1, 2019
This review examines demyelination and remyelination after SCI, focusing on oligodendrocyte lineage cell responses to spinal trauma and the prolonged response of NG2+ OPCs. The injured spinal cord is ...
KEY FINDING: OPCs proliferate and differentiate into myelinating oligodendrocytes for months after SCI.
Cell Death and Disease, 2022 • May 12, 2022
This study used single-cell RNA sequencing to analyze immune cell dynamics after spinal cord injury (SCI) in mice, revealing the heterogeneity of immune cells and the repopulation of microglia. The re...
KEY FINDING: Microglia repopulation after SCI is primarily derived from residual microglia, not from nestin+ stem cells.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study meticulously characterized the phenotypic diversity and plasticity of hGRP prepared by a Good Manufacturing Practice (GMP) production standard for possible clinical application. The study f...
KEY FINDING: hGRP and hGRP-derived astrocytes showed excellent survival and expressed astrocyte markers after transplantation into a spinal cord lesion.
Journal of Medicine and Life, 2009 • April 1, 2009
Cardiac dysfunctions are common consequences following SCI, and cardiovascular disturbances are the leading causes of morbidity and mortality in both acute and chronic phases. SCI disrupts pathways fr...
KEY FINDING: SCI associates significant cardiac dysfunction, particularly in patients with cervical or high thoracic injuries, leading to arrhythmias like bradycardia and hypotension.
BMJ Open Respir Res, 2025 • January 1, 2025
This study reports on 359 adults established on domiciliary MIE. The range of prescribed settings is narrow, reflecting the limited evidence base in this field and the need to better understand optima...
KEY FINDING: The most common diagnostic groups using MIE were congenital neuromuscular disease (26%), spinal cord injury (23%), and amyotrophic lateral sclerosis (23%).
Journal of NeuroEngineering and Rehabilitation, 2017 • June 28, 2017
This study evaluated the long-term performance of spiral nerve cuff electrodes implanted in 14 human volunteers for motor or sensory neuroprostheses. The results indicated that the majority of the imp...
KEY FINDING: The spiral nerve cuffs examined remain functional in motor and sensory neuroprostheses for 2–11 years after implantation.
Neural Regeneration Research, 2017 • October 1, 2017
Glial cells are resident cells in the CNS that play supporting, nutritional, and immunological roles. After SCI, signaling pathways activate/injure glial cells, inducing inflammation, glial scar forma...
KEY FINDING: Astrocytes directly or indirectly affect remyelination by acting on OPCs or oligodendrocytes. Specifically, astrocytes regulate the balance between Schwann cells and oligodendrocyte remyelination, with oligodendrocyte remyelination only observed in areas where astrocytes are present.
Journal of Medical Case Reports, 2022 • November 30, 2022
This case report describes an 81-year-old man who developed unilateral delayed post-hypoxic leukoencephalopathy (DPHL) following a dissection-related occlusion of the left carotid artery. The patient ...
KEY FINDING: Clinical symptoms suggestive of delayed post-hypoxic leukoencephalopathy (DPHL) can be observed in very rare cases following successful revascularization therapy in large vessel occlusions, causing acute ischemic stroke.
BMC Res Notes, 2017 • January 18, 2017
This case report highlights the diagnostic challenges of cobalamin deficiency, particularly in patients with SACD, and emphasizes the importance of considering alternative markers like MMA and homocys...
KEY FINDING: Normal cobalamin serum levels do not rule out a cobalamin deficiency, especially in cases of SACD.