Pathology Research

KEY FINDING: PlexinA4 is widely expressed throughout the adult rat brain, including the cortex, hippocampus, brainstem, pontine and medullary nuclei.

KEY FINDING: Fibroblasts are the major source of fibronectin in the fibrotic scar after spinal cord injury. Deletion of fibronectin in myeloid cells did not change fibronectin expression level, indicating that fibroblasts are likely the major source.

KEY FINDING: BM accelerated the recovery of motor function in rats with central nervous system injuries.

KEY FINDING: APRIL expression, along with its receptor BCMA, increases following spinal cord injury.

KEY FINDING: CD44 is upregulated during the formation of fibrotic scar after spinal cord injury.

KEY FINDING: MMC suppresses the growth of human epidural scar fibroblasts in a dose- and time-dependent manner.

KEY FINDING: S100A4 is upregulated in fibroblasts from ALS patients, regardless of the specific gene mutation, suggesting it is a common pathological trait.

KEY FINDING: Fibrotic scar tissue, composed of fibroblasts and excess extracellular matrix, forms after SCI and inhibits axonal regeneration.

KEY FINDING: Small surgical approach to debridement (SSAD) effectively removed hemorrhagic necrosis after acute cord contusion in rats.

KEY FINDING: Glial scar formation involves the activation of resident astrocytes, which surround the lesion core and wall off intact neurons in neurological damages.