Pharmacology Research

KEY FINDING: 5-FU administration after spinal cord injury improved hind limb sensorimotor function.

KEY FINDING: Stem cell therapy, particularly using Mesenchymal Stem Cells (MSCs) and Neural Stem Cells (NSCs), shows promise for treating SCI, although firm evidence of a cure is lacking.

KEY FINDING: Tandospirone (TDS) ameliorated visceral hypersensitivity and anxiety-like behavior induced by water avoidance stress.

KEY FINDING: G-CSF generally downregulates neurogenic differentiation markers in most brain regions studied.

KEY FINDING: DrSim outperforms existing methods in drug annotation, showing higher accuracy in predicting the mechanisms of action (MOAs) of compounds.

KEY FINDING: 164 potential active compounds from XCHD were screened to act on 95 HF-related targets.

KEY FINDING: Amnion products show promising effects in reducing epidural adhesions and scar tissue after spine surgery.

KEY FINDING: Clemastine enhances oligodendrocyte differentiation and myelination, which helps to delay axonal degeneration and promote motor function recovery in rat SCI models.

KEY FINDING: Andro treatment significantly improved tissue repair and functional recovery after SCI by reducing apoptosis, oxidative stress, and inflammation through the Nrf-2/HO-1 and NF-κB signaling pathways.

KEY FINDING: RSV exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines like IL-1β, IL-6, IL-8, and TNF-α, which ameliorates IDD progression mediated by inflammation.