Browse the latest research summaries in the field of pulmonology for spinal cord injury patients and caregivers.
Showing 121-130 of 154 results
Cochrane Database of Systematic Reviews, 2013 • July 1, 2013
This review investigated the effectiveness of respiratory muscle training (RMT) for individuals with cervical spinal cord injury (SCI). RMT aims to improve respiratory function, dyspnoea, respiratory ...
KEY FINDING: RMT has a statistically significant effect on vital capacity, maximal inspiratory pressure, and maximal expiratory pressure in individuals with cervical SCI.
Respir Physiol Neurobiol, 2013 • December 1, 2013
This prospective case-controlled clinical study was undertaken to investigate to what extent the manually assisted treadmill stepping Locomotor Training with body weight support (LT) can change respir...
KEY FINDING: FVC, FEV1, PImax, PEmax, amount of overall sEMG activity and rate of motor unit recruitment were significantly increased after LT (p<0.05)
Tanaffos, 2012 • January 1, 2012
Noninvasive respiratory management, including NIV and MAC, is effective in avoiding respiratory failure, hospitalizations, and tracheotomy for patients with NMDs and SCI who have functioning bulbar mu...
KEY FINDING: NIV and MAC can prevent respiratory failure, hospitalizations, and tracheostomies in NMD and SCI patients with functioning bulbar musculature.
Neurobiol Dis., 2021 • July 1, 2021
The study investigates the effectiveness of PAP4 in promoting respiratory axon regeneration and functional recovery in a rat model of chronic cervical spinal cord injury (SCI). PAP4 administration led...
KEY FINDING: Systemic delivery of PAP4 starting at 8 weeks after C2 hemisection promoted substantial, long-distance regeneration of injured bulbospinal rostral Ventral Respiratory Group (rVRG) axons.
Crit Care, 2021 • June 29, 2021
This study identifies CEA as a potential biomarker for COVID-19 patients, exploring its underlying mechanism through single-cell transcriptomics. The research reveals that developing neutrophils/neutr...
KEY FINDING: CEA was identified as the only laboratory indicator with a significant difference in both univariate and multivariate analyses.
Exp Neurol, 2017 • January 1, 2017
This review discusses the potential of cell transplantation for addressing respiratory dysfunction following spinal cord injury (SCI). It highlights the limited number of studies that have explored th...
KEY FINDING: Peripheral nerve grafts (PNGs) can promote the regrowth of respiratory-associated axons after SCI. Combining PNGs with chondroitinase ABC (ChABC) to remove growth inhibitors can enhance functional recovery of the diaphragm.
Exp Neurol., 2018 • May 1, 2018
This study investigated the potential of cRheb to promote regeneration of injured respiratory axons after cervical spinal cord injury (SCI) in rats. The researchers found that cRheb expression in rVRG...
KEY FINDING: Expression of cRheb selectively in rVRG neurons following cervical hemisection SCI stimulates mTOR pathway activation within transduced cells.
JOURNAL OF NEUROTRAUMA, 2019 • June 15, 2019
This study investigates the potential of chondroitinase ABC (ChABC) to enhance plasticity and recover respiratory motor function after severe midcervical contusion injury in rats. The key finding is t...
KEY FINDING: ChABC treatment at chronic stages post-cervical contusion injury leads to recovery of normal activity in the ipsilateral hemidiaphragm.
ENEURO, 2019 • August 19, 2019
This study investigated the effect of promoting axon regeneration on respiratory function after cervical spinal cord injury (SCI) in rats. Systemic administration of a PTEN antagonist peptide (PAP4) p...
KEY FINDING: Systemic administration of PAP4 promoted significant functional recovery of diaphragmatic respiratory function after cervical SCI.
Neurobiol Dis, 2021 • January 1, 2021
This study investigates the effects of a novel LAR inhibitory peptide on respiratory function after cervical spinal cord injury (SCI) in rats. The results demonstrate that LAR peptide promotes recover...
KEY FINDING: LAR peptide significantly improved ipsilateral hemidiaphragm function, as assessed in vivo with electromyography recordings.