Pulmonology Research

KEY FINDING: Pharmacological intervention which can increase central respiratory drive might be a potential way to induce recovery of the ipsilateral hemidiaphragm following C2 hemisection – without contralateral phrenicotomy.

KEY FINDING: ChABC treatment alone promotes plasticity of spared tracts and restores limited activity to the paralyzed diaphragm.

KEY FINDING: Pharmacological treatments, such as theophylline, can partially restore function to the paralyzed hemidiaphragm by increasing respiratory drive.

KEY FINDING: Prophylactic iNPPV was associated with a lower incidence of pneumonia compared to usual care in patients with acute CSCIs.

KEY FINDING: Both ipratropium bromide (IB) and albuterol sulfate (AS) elicit significant bronchodilation in subjects with tetraplegia, as demonstrated by improvements in spirometry and specific airway conductance.

KEY FINDING: All 5 ECMO-supported patients were successfully weaned, and one of the two iLA-treated patients was weaned from the device.

KEY FINDING: GI increased total lung capacity (TLC), vital capacity (VC), airway pressure (Paw), and heart rate (HR) in the CSCI group in a sitting position, while mean arterial blood pressure (MAP) decreased.

KEY FINDING: Diaphragm atrophies due to paralysis of abdominal muscles after SCI, leading to impaired lung ventilation and reduced venous return.

KEY FINDING: hMSCs are well tolerated in the murine model of acute asthma, suggesting that hMSCs can favorably change the outcome of asthmatic inflammation without the pathology associated with cross-species application.

KEY FINDING: Most patients who were still alive wanted to be ventilated again if needed, highlighting a will to live despite their condition.