Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 2,311-2,317 of 2,317 results
Nature Communications, 2019 • September 6, 2019
The spinal injury scar is a complex entity comprising various cell types and extracellular components that interplay to modulate tissue repair and regeneration after spinal cord injury. Reactive astro...
KEY FINDING: The spinal injury scar comprises multiple cellular and extracellular components beyond just glial cells, including fibroblasts, immune cells, and extracellular matrix.
Signal Transduction and Targeted Therapy, 2022 • July 21, 2022
This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human dise...
KEY FINDING: BM-MSCs are potentially good candidates for brain and spinal cord injury treatment.
Pharmaceutics, 2022 • March 29, 2022
With the deep understanding of the effector mechanisms of immune cells, the biomimetic and materials-potentiated cell engineering is refreshing its meaning. The combination of cell or cell-derived com...
KEY FINDING: Materials-potentiated cell engineering strategies are to endow immune cells with different supportive components (also known as backpack strategies), or functional materials to enhance their anti-tumor effects, prevent and rescue their dysfunction, maintain and restore their anti-tumor phenotype
Regeneration, 2017 • January 1, 2017
This study investigated the applicability of propofol as an immersion anesthetic in axolotls, focusing on its effects on cardiovascular function, action potential propagation in the spinal cord, and g...
KEY FINDING: Propofol has significantly less cardiovascular effect than benzocaine and MS-222 when used as an anesthetic in axolotls.
Nature Communications, 2022 • November 4, 2022
This study investigates the role of estrogen in skeletal regeneration, revealing a sexually dimorphic response in mice. Female mice depend on estrogen for skeletal stem cell (SSC) mediated bone regene...
KEY FINDING: Skeletal regeneration is sexually dimorphic: female mice require estrogen for skeletal stem cell-mediated bone regeneration, while male mice do not exhibit similar estrogen responsiveness.
Cells, 2022 • November 22, 2022
This study compared the time course of neuronal, glial, and sensorimotor recovery in A/J and C57BL/6J mice following sciatic nerve crush. A/J mice showed higher expression of MHC-I, Iba-1 (microglial ...
KEY FINDING: MHC-I upregulation peaks at 7 days postinjury in both C57BL/6J and A/J mice, but is significantly higher in the A/J strain.
Neural Regeneration Research, 2022 • March 1, 2022
Traumatic spinal cord injuries (SCI) disrupt the connection between the brain and spinal cord neurons, leading to impaired movement. Axon regeneration has been considered the Holy Grail in SCI researc...
KEY FINDING: Netrin-1 promotes significant regeneration of axonal tracts localized at the white matter segment across the transected area.